The environment rules: spatiotemporal regulation of oligodendrocyte differentiation.
The environment rules: spatiotemporal regulation of oligodendrocyte differentiation.
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DOI：
10.1016/j.conb.2016.04.002
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发表时间：
2016-08
影响因子：
5.7
通讯作者：
Chan JR
中科院分区：
文献类型：
--
作者：
Mayoral SR;Chan JR
在发育过程中，少突胶质前体细胞（OPCs）迅速增殖并迁移到整个中枢神经系统。OPCs的动员之后是终末分化为成熟的少突胶质细胞和随后的轴突髓鞘形成。OPCs的分化是CNS范围内的和强大的，但在空间和时间上受到限制。是什么因素控制着这种精确而协调的差异化努力？我们讨论了内在和外在的线索在调节OPC分化的证据，并收集外部线索发挥主导作用，在调节OPCs分化为成熟的少突胶质细胞。
During development oligodendrocyte precursor cells (OPCs) rapidly proliferate and migrate throughout the central nervous system. The mobilization of OPCs is followed by terminal differentiation into mature oligodendrocytes and the subsequent myelination of axons. Differentiation of OPCs is CNS-wide and robust, and yet spatially and temporally restricted. What factors control this precise and coordinated differentiation effort? We discuss evidence for both intrinsic and extrinsic cues in regulating OPC differentiation and gather that extrinsic cues play the leading role in regulating the differentiation of OPCs into mature oligodendrocytes.