STATIC CIRCUMFERENTIAL TANGENTIAL MODULUS OF HUMAN ATHEROSCLEROTIC TISSUE
STATIC CIRCUMFERENTIAL TANGENTIAL MODULUS OF HUMAN ATHEROSCLEROTIC TISSUE
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DOI：
10.1016/0021-9290(94)90209-7
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发表时间：
1994-02-01
影响因子：
2.4
通讯作者：
LEE, RT
中科院分区：
文献类型：
--
作者：
LOREE, HM;GRODZINSKY, AJ;LEE, RT
动脉粥样硬化斑块的力学特性可能对斑块破裂的过程至关重要，这是心肌梗死最常见的前兆。为了研究斑块结构和外加拉伸应力对动脉粥样硬化斑块静态周向切向模量的影响，研究了26个人主动脉内膜斑块的应力-应变行为。在21例患者的常规尸检中，从腹部（n = 19）和胸部（n = 2）主动脉收集内膜斑块，并根据组织学分析分为细胞性（n = 12）、低细胞性（n = 9）和钙化（n = 5）。在25 kPa的生理施加周向拉伸应力下，细胞、低细胞和钙化标本的切向模量分别为927 +/- 468 kPa、2312 +/- 2180 kPa和1466 +/- 1284 kPa。在25 kPa应力下，细胞和低细胞（p = 0.098）、细胞和钙化（p = 0.410）、细胞和钙化（p = 0.380）样品的切向模量差异不显著。这与先前测量的斑块组织径向压缩行为形成鲜明对比，后者表明细胞斑块、低细胞斑块和钙化斑块的模量有显著差异。在张力下，所有26个斑块测试显示，随着施加周向应力的增加，切向模量有统计学意义的增加。我们得出结论，动脉粥样硬化斑块的静态周向切向模量，与其径向压缩模量不同，不受组织学特征决定的细胞化程度和钙化程度的显著影响。细胞斑块和低细胞斑块在负载的生理范围内表现出强烈的各向异性和非线性特性，其周向切向模量约为先前报道的径向压缩模量的20倍。
The mechanical properties of atherosclerotic plaque may be of critical importance to the processes of plaque rupture, the most common antecedent of myocardial infarction. To investigate the effects of plaque structure and applied tensile stress on the static circumferential tangential modulus of atherosclerotic plaque, the stress-strain behavior of 26 human aortic intimal plaques was studied. Intimal plaques were collected during routine autopsies of 21 patients from the abdominal (n = 19) and thoracic (n = 2) aorta and were classified by histological analysis as cellualr (n = 12), hypocellular (n = 9), and calcified (n = 5). At a physiologic applied circumferential tensile stress of 25 kPa, the tangential moduli of cellular, hypocellular, and calcified specimens were 927 +/- 468 kPa, 2312 +/- 2180 kPa, and 1466 +/- 1284 kPa, respectively. There was a nonsignificant difference in tangential modulus at 25 kPa stress between specimens classified as cellular and hypocellular (p = 0.098), cellular and calcified (p = 0.410), and hypocellular and calcified (p = 0.380). This is in marked contrast to the previously measured radial compressive behavior of plaque tissue, which showed that cellular, hypocellular, and calcified plaques were significantly different in their modulus. In tension, all 26 plaques tested demonstrated a statistically significant increase in tangential modulus with increasing applied circumferential stress. We conclude that the static circumferential tangential modulus of atherosclerotic plaque, unlike its radial compressive modulus, is not significantly affected by the degree of cellularity and calcification determined by histological characterization. Cellular and hypocellular plaques exhibit strongly anisotropic and nonlinear properties in the physiologic range of loading, with circumferential tangential modulus about 20 times greater than previously reported measurements of radial compressive modulus.