EFFECT OF CIGARETTE-SMOKING ON SUSCEPTIBILITY TO EPIDEMIC INFLUENZA AND ON SEROLOGICAL RESPONSES TO LIVE ATTENUATED AND KILLED SUBUNIT INFLUENZA VACCINES
EFFECT OF CIGARETTE-SMOKING ON SUSCEPTIBILITY TO EPIDEMIC INFLUENZA AND ON SEROLOGICAL RESPONSES TO LIVE ATTENUATED AND KILLED SUBUNIT INFLUENZA VACCINES
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DOI：
10.1017/s0022172400055790
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发表时间：
1976-01-01
影响因子：
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通讯作者：
HOLT, PG
中科院分区：
文献类型：
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作者：
MACKENZIE, JS;MACKENZIE, IH;HOLT, PG
在西澳大利亚州的比较疫苗试验中，研究了吸烟对流行性流感发病率以及对灭活亚单位流感疫苗和减毒活疫苗的血清学反应的影响。流行前没有血凝抑制（HI）抗体（滴度≤12）的吸烟者比不吸烟者更容易感染流行性流感。如果吸烟者拥有可检测到的流行前 HI 抗体，他们也不会更容易受到影响。 A significantly higher proportion of smokers seroconverted after receiving the live virus vaccine than their non-smoking counterparts, but this could not be correlated with pre-vaccination HI antibody titers.对于在接种前几乎没有或没有免疫力的吸烟者来说，在接种后50周，对亚单位疫苗的免疫反应的寿命严重降低（效价≤12）。在活病毒疫苗或具有接种前HI抗体的亚单位疫苗中没有观察到这种抗体缺陷（效价≥24）。无论疫苗组或吸烟史如何，疫苗后症状都相似。
The effects of cigarette smoking on the incidence of epidemic influenza and on the serological response to influenza vaccination with killed subunit and live attenuated vaccines were investigated during comparative vaccines trials in W Australia. Cigarette smokers with no pre-epidemic hemagglutination-inhibiting (HI) antibody (titers .ltoreq. 12) were significantly more susceptible to epidemic influenza than non-smokers. Smokers were no more susceptible if they possessed detectable pre-epidemic HI antibody. A significantly higher proportion of smokers seroconverted after receiving the live virus vaccine than their non-smoking counterparts, but this could not be correlated with pre-vaccination HI antibody titers. The longevity of the immune response to the subunit vaccine was severely depressed 50 wk post-vaccination in smokers who had possessed little or no immunity before vaccination (titers .ltoreq. 12). This antibody deficit was not observed in live virus vaccines or subunit vaccines with pre-vaccination HI antibody (titers .gtoreq. 24). Post-vaccinal symptoms were similar regardless of vaccine group or smoking history.