Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis.
Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis.
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DOI：
10.3389/fcimb.2015.00077
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发表时间：
2015
影响因子：
5.7
通讯作者：
Lu NH
中科院分区：
文献类型：
--
作者：
Li N;Xie C;Lu NH
幽门螺杆菌(Hp)是一种革兰氏阴性、微需氧、螺旋杆菌，特异性地定植于胃粘膜。毒力因素、宿主遗传因素和环境因素的相互作用导致了幽门螺杆菌相关性疾病的发生，如萎缩性胃炎和肠化生。幽门螺杆菌感染最近被认为是胃癌的最大危险因素。转化生长因子-β作为一种多效性细胞因子，调节细胞周期、增殖、凋亡和转移等多种生物学过程。最近的研究为转化生长因子-β信号通路在幽门螺杆菌感染发病机制中的作用提供了新的线索。本文就转化生长因子-β在幽门螺杆菌介导的胃病发病机制中的潜在病因学作用作一综述。
Helicobacter pylori (H.pylori) is a Gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. The interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of H. pylori-associated conditions, such as atrophic gastritis and intestinal metaplasia. Infection with H. pylori has recently been recognized as the strongest risk factor for gastric cancer. As a pleiotropic cytokine, transforming growth factor (TGF)-β regulates various biological processes, including cell cycle, proliferation, apoptosis, and metastasis. Recent studies have shed new light on the involvement of TGF-β signaling in the pathogenesis of H. pylori infection. This review focuses on the potential etiological roles of TGF-β in H. pylori-mediated gastric pathogenesis.