Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD
Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD
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DOI：
10.1194/jlr.p600005-jlr200
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发表时间：
2006-12-01
影响因子：
6.5
通讯作者：
Lichtenstein, Alice H.
中科院分区：
文献类型：
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作者：
Erkkila, Arja T.;Matthan, Nirupa R.;Lichtenstein, Alice H.
鱼类摄入量、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）以及某些情况下的α-亚麻酸（ALA）与心血管事件和死亡风险降低有关。在已确诊的冠状动脉疾病（CAD）女性中评估了血脂中n（-3）脂肪酸与冠状动脉粥样硬化进展之间的关系。一项前瞻性队列研究涉及绝经后妇女（n = 5 228）参加雌激素替代和动脉粥样硬化试验。在基线和3.2 +/- 0.6（平均值+/- SD）年后进行定量冠状动脉造影。血浆磷脂（PL）DHA水平高于中位数的女性，与低于中位数的女性相比，动脉粥样硬化进展较少，表现为最小冠状动脉直径的下降（分别为20.04 +/- 0.02和20.10 +/- 0.02 mm; P = 0.007）或狭窄百分比增加（分别为1.34 +/- 0.76%和3.75 +/-0.74%; P = 0.006），新病变较少[2.0%（0.5-3.5%）的测量节段（95%置信区间）和4.2%（2.8-5.6%）; P = 0.009]调整心血管风险因素后。在甘油三酯（TG）中观察到DHA的类似结果。血浆中EPA和ALA与动脉粥样硬化进展无明显相关性。与报道的较高的鱼类摄入量一致，较高水平的血浆TG和PL DHA与绝经后CAD女性冠状动脉粥样硬化进展较少相关。
Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases a-linolenic acid ( ALA) have been associated with reduced risk of cardiovascular events and death. The association between n(-3) fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed among women with established coronary artery disease ( CAD). A prospective cohort study involved postmenopausal women (n = 5 228) participating in the Estrogen Replacement and Atherosclerosis Trial. Quantitative coronary angiography was performed at baseline and after 3.2 +/- 0.6 ( mean +/- SD) years. Women with plasma phospholipid (PL) DHA levels above the median, compared with below, exhibited less atherosclerosis progression, as expressed by decline in minimum coronary artery diameter (20.04 +/- 0.02 and 20.10 +/- 0.02 mm, respectively; P = 0.007) or increase in percentage stenosis (1.34 +/- 0.76% and 3.75 +/- 0.74%, respectively; P = 0.006), and had fewer new lesions [2.0% (0.5-3.5%) of measured segments (95% confidence interval) and 4.2% (2.8-5.6%), respectively; P = 0.009] after adjustments for cardiovascular risk factors. Similar results were observed for DHA in the triglycerides (TGs). EPA and ALA in plasma lipids were not significantly associated with atherosclerosis progression. Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD.