Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster
Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster
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DOI：
10.1038/nn1371
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发表时间：
2005-01-01
影响因子：
25
通讯作者：
Hatt, H
中科院分区：
文献类型：
--
作者：
Neuhaus, EM;Gisselmann, G;Hatt, H
尽管人们对G蛋白偶联受体的二聚化有了越来越多的了解，但对气味受体这个最大的亚家族的二聚化却一无所知。结合使用生化和电生理学方法，我们在这里证明了气味受体可以二聚化。DOR83b是一种气味受体，广泛表达于果蝇的嗅觉神经元中，在昆虫中高度保守，与其他气味受体蛋白形成异二聚体复合体，大大增强了它们的功能。
Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the largest subfamily, odorant receptors. Using a combination of biochemical and electrophysiological approaches, we demonstrate here that odorant receptors can dimerize. DOR83b, an odorant receptor that is ubiquitously expressed in olfactory neurons from Drosophila melanogaster and highly conserved among insect species, forms heterodimeric complexes with other odorant-receptor proteins, which strongly increases their functionality.