11C-Acetate can be Used in Place of 18F-Fluorodeoxyglucose for Positron Emission Tomography Imaging of Non-small Cell Lung Cancer with Higher Sensitivity for Well-Differentiated Adenocarcinoma
11C-Acetate can be Used in Place of 18F-Fluorodeoxyglucose for Positron Emission Tomography Imaging of Non-small Cell Lung Cancer with Higher Sensitivity for Well-Differentiated Adenocarcinoma
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DOI：
10.1097/jto.0b013e31818ddfdc
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发表时间：
2008-12-01
影响因子：
20.4
通讯作者：
Horio, Hirotoshi
中科院分区：
文献类型：
--
作者：
Nomori, Hiroaki;Shibata, Hidekatsu;Horio, Hirotoshi
Objectives: Although positron emission tomography (PET) using F-18-fluorodeoxy-glucose (FDG) frequently gives false-negative results for slow-growing tumors, C-11-acetate (AC)-PET has been reported to be able to detect them. To determine the usefulness of AC-PET for imaging non-small cell lung cancers (NSCLCs), the sensitivity and specificity were compared between the AC-PET and FDG-PET with a Multicenter study.Materials and Methods: A total of 284 pulmonary lesions (227 NSCLCs and 57 benign lesions) were examined using both AC-PET and FDG -PET before surgery at seven Japanese institutes. The AC-or FDG-uptake in each lesion were quantitatively measured using the contrast ratio of the standard uptake value between the lesions and the contralateral lung.Results: The sensitivity of AC-PET for diagnosing NSCLC was 0.71, which was significantly higher than the value of 0.57 obtained by FDG-PET (p < 0.001). No significant difference in the specificity was seen between AC- and FDG-PFT. For the 146 well-differentiated adenocarcinomas. the sensitivity of AC-PET was 0.62, which was significantly higher than the value of 0.37 obtained by FDG-PET (p < 0.001). Of the 51 moderately- or poorly-differentiated adenocarcinomas and 30 nonadenocarcinomas, there was no significant difference of sensitivity between AC- and FDG-PET.Conclusions: AC-PET could be used in place of FDG-PET for imaging NSCLC, with higher sensitivity for well-differentiated adenocarcinoma compared with FDG-PET.
