Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice
Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice
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DOI：
10.1016/s0166-4328(01)00378-3
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发表时间：
2002-04-01
影响因子：
2.7
通讯作者：
Saito, S
中科院分区：
文献类型：
--
作者：
Onozuka, M;Watanabe, K;Saito, S
用生化、形态和行为学方法研究了老年SAMP8小鼠上磨牙摘除后海马区糖皮质激素反应的变化。无磨牙小鼠的血浆皮质酮水平显著高于磨牙完整的对照组小鼠。美托拉酮可抑制应激引起的血浆皮质酮水平升高，阻止无磨牙状态下血浆皮质酮水平升高、CA1区锥体神经元数量减少和空间学习障碍。结果表明，无磨牙状态与糖皮质激素反应之间存在联系，这可能与老年SAMP8小鼠的空间学习障碍和海马神经元死亡有关。(C)2002 Elsevier Science B.V.保留所有权利。
The involvement of glucocorticoid response in the hippocampal changes in aged SAMP8 mice after removal of their upper molar teeth (molarless condition) was examined using biochemical, morphological and behavioral techniques. Molarless mice showed plasma corticosterone levels to be significantly greater than those in molar-intact control mice. Pretreatment with metyrapone, which suppresses the stress-induced rise in plasma corticosterone levels, prevented the molarless condition-induced increase in plasma corticosterone levels, reduction in CAI pyramidal neuron numbers, and impairment of spatial learning. The results suggest a link between the molarless condition and the glucocorticoid response, which may be involved in spatial learning deficits and hippocampal neuronal death in aged SAMP8 mice. (C) 2002 Elsevier Science B.V. All rights reserved.