Thirty-month naturalistic follow-up study of early-onset dysthymic disorder: Course, diagnostic stability, and prediction of outcome
Thirty-month naturalistic follow-up study of early-onset dysthymic disorder: Course, diagnostic stability, and prediction of outcome
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DOI：
10.1037/0021-843x.107.2.338
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发表时间：
1998-05-01
影响因子：
4.6
通讯作者：
Aronson, TA
中科院分区：
文献类型：
--
作者：
Klein, DN;Norden, KA;Aronson, TA
恶劣心境障碍(DD)的定义和与严重抑郁障碍(MDD)的区别很大程度上是基于其病程。然而，令人惊讶的是，很少有前瞻性的、纵向的关于DD的自然主义过程的研究。本文报道了对86例早发性DD(EOD)门诊患者和39例发作性MDD门诊患者进行的前瞻性、纵向30个月随访研究的主要结果。随访评估包括纵向间隔随访评估和汉密尔顿抑郁量表。与发作性MDD患者相比，EOD患者比基线评估改善更少，在随访时症状更多。只有39%的EOD患者在随访期内从DD中恢复过来。DD的诊断相当稳定，52%的EOD组在随访时达到了DD的全部标准。这些数据为本病的慢性病程提供了前瞻性的证实。
Dysthymic disorder (DD) is defined and distinguished from major depressive disorder (MDD) largely on the basis of its course. Surprisingly, however, there have been few prospective, longitudinal studies of the naturalistic course of DD. This article reports the major findings from a prospective, longitudinal 30-month follow-up study of 86 outpatients with early-onset DD (EOD) and 39 outpatients with episodic MDD. Follow-up assessments included the Longitudinal Interval Follow-Up Evaluation and Hamilton Rating Scale for Depression. Compared with patients with episodic MDD, patients with EOD exhibited less improvement from the baseline evaluation and were more symptomatic at follow-up. Only 39% of patients with EOD recovered from DD during the follow-up period. The diagnosis of DD was fairly stable, with 52% of the EOD group meeting full criteria for DD at follow-up. These data provide prospective confirmation of the chronic course of DD.