A general method for the formation of aryl-sulfur bonds using copper(I) catalysts
A general method for the formation of aryl-sulfur bonds using copper(I) catalysts
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DOI：
10.1021/ol0264105
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发表时间：
2002-08-08
期刊：
影响因子：
5.2
通讯作者：
Venkataraman, D
中科院分区：
文献类型：
--
作者：
Bates, CG;Gujadhur, RK;Venkataraman, D
[图表]我们报告了一种温和的无钯合成方案，用于芳基碘和硫醇的交叉偶联反应，使用10 mol % Cul和10 mol %新亚铜灵，以NaOt-Bu为碱，在甲苯中在110 ℃下进行。使用这种协议，我们已经表明，各种芳基硫醚可以合成优良的产率从容易获得的碘化物和硫醇。
[GRAPHICS]We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % Cul and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degreesC. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.