Yogurt containing Probiotic Lactobacillus rhomnosus GR-1 and L-reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/AIDS patients
Yogurt containing Probiotic Lactobacillus rhomnosus GR-1 and L-reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/AIDS patients
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DOI：
10.1097/mcg.0b013e31802c7465
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发表时间：
2008-03-01
影响因子：
2.9
通讯作者：
Reid, Gregor
中科院分区：
文献类型：
--
作者：
Anukam, Kingsley C.;Osazuwa, Emanual O.;Reid, Gregor
艾滋病毒/艾滋病正在改变撒哈拉以南非洲的人类景观。接受抗逆转录病毒治疗的患者相对较少，许多人患有使人衰弱的腹泻，影响了他们的生活质量。鉴于益生菌缓解腹泻的记录，用德氏乳杆菌保加利亚变种和嗜热链球菌发酵的常规酸奶补充益生菌鼠李糖乳杆菌GR-1和L. reuteri RC-14。24例HIV/AIDS成年女性患者（18至44岁），临床症状为中度腹泻，CD 4计数超过200，未接受抗逆转录病毒药物或膳食补充剂，每天食用100 mL补充或未补充酸奶，持续15天。在基线、益生菌酸奶喂养后15天和30天评估血液学特征、CD 4细胞计数和生活质量。在益生菌酸奶喂养前后，两组的血液学参数没有显著变化。益生菌酸奶组在基线、第15天和第30天的平均WBC计数分别为5.8 +/- 0.76 x 10（9）/L、6.0 +/- 1.02 x 10（9）/L和5.4 +/- 0.14 x 10（9）/L。然而，与对照组的3/12相比，益生菌治疗组的11/12受试者的平均CD 4细胞计数在15天和30天时保持相同或增加。腹泻、肠胃气胀和恶心在12/12的益生菌治疗的受试者中在2天内解决，而在15天内接受酸奶的受试者中有2/12。这是第一项显示益生菌酸奶对尼日利亚艾滋病毒/艾滋病妇女生活质量的益处的研究，并表明也许一种简单的发酵食品可以在非洲艾滋病流行的管理中提供一些缓解。
HIV/AIDS is changing the human landscape in sub-Saharan Africa. Relatively few patients receive antiretroviral therapy, and many suffer from debilitating diarrhea that affects their quality of life. Given the track record of probiotics to alleviate diarrhea, conventional yogurt fermented with Lactobacillus delbruekii var bulgaricus and Streptococcus thermophilus was supplemented with probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14. Twenty-four HIV/AIDS adult female patients (18 to 44y) with clinical signs of moderate diarrhea, CD4 counts over 200, and not receiving antiretrovirals or dietary supplements, consumed either 100mL supplemented or unsupplemented yogurt per day for 15 days. Hematologic profiles, CD4 cell counts, and quality of life was evaluated at baseline, 15 and 30 days postprobiotic-yogurt feeding. There was no significant alteration in the hematologic parameters of both groups before and after the probiotic-yogurt feeding. The probiotic yogurt group at baseline, 15 and 30 days had a mean WBC count of 5.8 +/- 0.76 x 10(9)/L, 6.0 +/- 1.02 x 10(9)/L, and 5.4 +/- 0.14 x 10(9)/L, respectively. However, the mean CD4 cell count remained the same or increased at 15 and 30 days in 11/12 probiotic-treated subjects compared to 3/12 in the control. Diarrhea, flatulence, and nausea resolved in 12/12 probiotic-treated subjects within 2 days, compared to 2/12 receiving yogurt for 15 days. This is the first study to show the benefits of probiotic yogurt on quality of life of women in Nigeria with HIV/AIDS, and suggests that perhaps a simple fermented food can provide some relief in the management of the AIDS epidemic in Africa.