Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: a nuclear family study
Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: a nuclear family study
复制标题
DOI：
10.1111/jsr.12168
复制
发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Vela-Bueno, Antonio
中科院分区：
文献类型：
--
作者：
Fernandez-Mendoza, Julio;Shaffer, Michele L.;Vela-Bueno, Antonio
认知-情绪过度觉醒被认为是失眠的诱发因素;然而，关于失眠和认知-情绪过度觉醒的家族易感性的关联信息有限。本研究的目的是评估压力相关失眠的遗传性，并检查父母对压力相关失眠的脆弱性是否与其后代的认知情绪过度觉醒有关。我们研究了135个核心家庭的志愿者样本，包括270名中年（51.5 +/- 5.4岁）的父亲和母亲以及他们的一个生物后代（n = 135，20.2 +/- 1.1岁）。我们测量了所有参与者对压力相关失眠的脆弱性（即福特压力反应测试：第一），感知压力，抑郁和焦虑，以及后代的唤醒能力，前视认知和躯体唤醒，应对和个性。我们发现FIRST分数的遗传率估计为29%。高FIRST的父母有三到七倍的几率让后代非常容易受到压力相关失眠的影响。高FIRST父母的后代表现出较高的唤醒能力、前认知唤醒和情绪导向应对。此外，高FIRST的母亲有助于后代的较高的焦虑和较低的任务导向应对，而高FIRST的父亲有助于后代的较高的前躯体唤醒和警觉性。易患与压力有关的失眠症是明显遗传的。易患压力相关失眠症的父母，其子女的认知-情绪过度觉醒依赖于情绪导向的应对方式。这些数据支持唤醒能力和适应不良应对是失眠病因学的关键因素的观点。
Cognitive-emotional hyperarousal is believed to be a predisposing factor for insomnia; however, there is limited information on the association of familial vulnerability to insomnia and cognitive-emotional hyperarousal. The aim of this study was to estimate the heritability of stress-related insomnia and examine whether parental vulnerability to stress-related insomnia is associated with cognitive-emotional hyperarousal in their offspring. We studied a volunteer sample of 135 nuclear families comprised of 270 middle-aged (51.5 +/- 5.4 years) fathers and mothers and one of their biological offspring (n = 135, 20.2 +/- 1.1 years). We measured vulnerability to stress-related insomnia (i.e. Ford Insomnia Response to Stress Test: FIRST), perceived stress, depression and anxiety in all participants, and arousability, presleep cognitive and somatic arousal, coping and personality in the offspring. We found a heritability estimate of 29% for FIRST scores. High FIRST parents had three to seven times the odds of having offspring highly vulnerable to stress-related insomnia. Offspring of high FIRST parents showed higher arousability, presleep cognitive arousal and emotion-oriented coping. Furthermore, high FIRST mothers contributed to offspring's higher anxiety and lower task-oriented coping, while high FIRST fathers contributed to offspring's higher presleep somatic arousal and conscientiousness. Vulnerability to stress-related insomnia is significantly heritable. Parents vulnerable to stress-related insomnia have offspring with cognitive-emotional hyperarousal who rely upon emotion-oriented coping. These data give support to the notion that arousability and maladaptive coping are key factors in the aetiology of insomnia.