Effects of dorsal hippocampal damage on conditioning and conditioned-response timing: A pooled analysis
Effects of dorsal hippocampal damage on conditioning and conditioned-response timing: A pooled analysis
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背侧海马损伤对条件反射和条件反应时间的影响：汇总分析
作者：
Tam S
行为研究结果表明，背海马（DHPC）起着重要的作用，在食欲条件反应的时间。本文探讨了DHPC损伤程度和计时能力之间的关系，在我们实验室的三个已发表的研究汇总分析。初步的方差分析证实了我们以前的报告，即DHPC损坏减少了峰值时间（计时精度的测量）。然而，扩散（计时精度的测量）未发生变化，因此DHPC损伤动物的变异系数（扩散/峰值时间）显著更大。这意味着，除了DHPC损伤对计时准确性的公认影响外，DHPC损伤还导致计时准确性不足。为了补充这一分析，在组合数据集上进行了不同的广义线性混合效应模型（GLSTF），以检查不同行为时间测量的组合是海马损伤程度的最佳预测因子。GLMM分析的结果表明，DHPC损伤越大，观察到的峰值时间和加固持续时间之间的绝对差异越大。然而，这种损伤和性能之间的系统关系并不特定于时间域：矛盾的是，损伤越大，峰值响应的幅度越大。我们讨论这些病变的标量定时理论方面的影响。© 2014 Wiley Periodicals，Inc.
Behavioral findings suggest that the dorsal hippocampus (DHPC) plays a role in timing of appetitive conditioned responding. The present article explored the relationship between the extent of DHPC damage and timing ability, in a pooled analysis of three published studies from our laboratory. Initial analyses of variance confirmed our previous reports that DHPC damage reduced peak time (a measure of timing accuracy). However, the spread (a measure of timing precision) was unchanged, such that the coefficient of variation (spread/peak time) was significantly larger in DHPC‐lesioned animals. This implies that, in addition to the well‐established effect of DHPC lesions on timing accuracy, DHPC damage produced a deficit in precision of timing. To complement this analysis, different generalized linear mixed‐effects models (GLMMs) were performed on the combined dataset, to examine which combinations of the different behavioral measures of timing were the best predictors of the degree of hippocampal damage. The results from the GLMM analysis suggested that the greater the DHPC damage, the greater the absolute difference between the observed peak time and reinforced duration. Nevertheless, this systematic relationship between damage and performance was not specific to the temporal domain: paradoxically the greater the damage the greater the magnitude of peak responding. We discuss these lesion effects in terms of scalar timing theory. © 2014 Wiley Periodicals, Inc.