Hydroxide‐catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles
Hydroxide‐catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles
复制标题
氢氧化物催化腈类杂环芳香胺衍生物的合成
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
R. Smithwick
中科院分区：
文献类型：
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作者：
N. Smyrl;R. Smithwick
介绍了一种由腈类化合物在氢氧化物催化下合成多种杂环芳香胺衍生物的通用方法。腈二聚体（3-氨基巴豆腈和双氰胺）和二聚体类似物（邻氨基苯腈）在氢氧化物存在下与单体腈反应，分别形成氨基嘧啶、二氨基三嗪和氨基喹唑啉。
A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented. Nitrile dimers (3-aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.