Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior
Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior
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DOI：
10.1038/sj.npp.1395364
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发表时间：
1999-08-01
影响因子：
7.6
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Mann, JJ
从系统发育来看，5-羟色胺能系统是大脑中最古老的递质系统之一。结合大多数皮质和皮质下结构的复杂和广泛的神经支配，以及十几种受体亚型，存在着多种信号机会和功能角色，解释了5-羟色胺与许多不同类型的精神病理疾病的联系。本文就5-羟色胺能系统在心境障碍和自杀行为倾向中的作用作一综述。对5-羟色胺能系统的影响是许多类型药物抗抑郁作用的基础，必须整合到情绪障碍的神经生物学模型中。(C)1999年美国神经精神药理学学院。爱思唯尔科学公司出版。
Phylogenetically, the serotonergic system is one of the oldest transmitter systems in the brain. Combining a complex and widespread innervation of most cortical and subcortical structures, with over a dozen receptor subtypes, there is a diversity of signaling opportunities and functional roles that explain the association of serotonin with many different types of psychopathological conditions. The role oft he serotonergic system in mood disorders and in the predisposition for suicidal behavior are reviewed in this paper. Effects on the serotonergic system underlie the antidepressant action of many types of medications and must be integrated into a neurobiological model of mood disorders. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.