Distinct population codes for attention in the absence and presence of visual stimulation.

Distinct population codes for attention in the absence and presence of visual stimulation.
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DOI:
10.1038/s41467-018-06754-5
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发表时间:
2018-10-22
影响因子:
16.6
通讯作者:
Smith MA
Smith MA
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Snyder AC;Yu BM;Smith MA

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视觉神经元对有人注意的刺激比无人注意的刺激反应更强烈。大脑如何在预期刺激的情况下为反应增益做准备还没有得到很好的理解。一个突出的建议是,预期的特点是类似于刺激反应的增益自发活动的增益样调制。在这里,我们测试另一种想法:预期的特点是自发放电率的增加和减少的混合物。这样的策略将是自适应的,因为它支持一个简单的线性方案,用于从外部的感觉输入中解开内部的调节信号。我们记录了执行注意力任务的猴子的V4神经元群体,并发现在存在或不存在刺激的情况下,注意力状态由整个群体中不同的神经元混合物发出信号。我们的研究结果支持从刺激不变的预期帐户走向更丰富的观点,在不同的神经元群体的注意力调节。注意力影响刺激反应增益,但其影响没有感觉驱动是鲜为人知的。在这里,作者表明,注意力在人群中是编码的,并且在未刺激和刺激的背景下是不同的,这与注意力的归一化增益模型形成了对比。
Visual neurons respond more vigorously to an attended stimulus than an unattended one. How the brain prepares for response gain in anticipation of that stimulus is not well understood. One prominent proposal is that anticipation is characterized by gain-like modulations of spontaneous activity similar to gains in stimulus responses. Here we test an alternative idea: anticipation is characterized by a mixture of both increases and decreases of spontaneous firing rates. Such a strategy would be adaptive as it supports a simple linear scheme for disentangling internal, modulatory signals from external, sensory inputs. We recorded populations of V4 neurons in monkeys performing an attention task, and found that attention states are signaled by different mixtures of neurons across the population in the presence or absence of a stimulus. Our findings support a move from a stimulation-invariant account of anticipation towards a richer view of attentional modulation in a diverse neuronal population. Attention affects stimulus response gain, but its impact without sensory drive is less known. Here, the authors show that attention is coded diversely in a population and is distinct between unstimulated and stimulated contexts, providing a contrast to normalized gain models of attention.
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