Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
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DOI：
10.1001/archneur.60.8.1059
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发表时间：
2003-08-01
影响因子：
--
通讯作者：
Ascherio, A
中科院分区：
文献类型：
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作者：
Chen, HL;Zhang, SMM;Ascherio, A
背景：非甾体抗炎药（NSAIDs）可减少帕金森病（PD）动物模型的多巴胺能神经元变性。然而，目前还没有关于非甾体抗炎药的使用和PD风险的流行病学数据。目的：前瞻性探讨非阿司匹林类非甾体抗炎药或阿司匹林是否与降低PD风险相关。设计、设置和参与者：44057名男性和98845名女性的前瞻性队列，无PD、中风或癌症（卫生专业人员随访研究，19862000，护士健康研究，1980-1998）。主要观察指标：新诊断的PD。结果：我们记录了415例PD病例（236例男性，179例女性）。在研究开始时报告经常使用非阿司匹林类非甾体抗炎药的参与者在随访期间患PD的风险低于不经常使用的参与者；合并多因素相对危险度为0.55（95%可信区间为0.32-0.96,P = 0.04）。与非使用者相比，每天服用2片或更多阿司匹林的男性和女性患PD的风险也不显著降低（相对风险，0.56；95%可信区间，0.26-1.21）。结论：这些发现与使用非甾体抗炎药可能延缓或预防PD发病的假设一致。
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce dopaminergic neuron degeneration in animal models of Parkinson disease (PD). However, no epidemiological data have been available on NSAID use and the risk of PD.Objective: To investigate prospectively whether the use of nonaspirin NSAIDs or aspirin is associated with decreased PD risk.Design, Settings, and Participants: Prospective cohorts of 44057 men and 98845 women free of PD, stroke, or cancer (Health Professionals Follow-up Study, 19862000, and Nurses' Health Study, 1980-1998).Main Outcome Measure: Newly diagnosed PD.Results: We documented 415 incident PD cases (236 men and 179 women). Participants who reported regular use of nonaspirin NSAIDs at the beginning of the study had a lower risk of PD than nonregular users during the follow-up; the pooled multivariate relative risk was 0.55 (95% confidence interval, 0.32-0.96, P = .04). Compared with nonusers, a nonsignificantly lower risk of PD was also observed among men and women who took 2 or more tablets of aspirin per day (relative risk, 0.56; 95% confidence interval, 0.26-1.21).Conclusion: These findings are consistent with the hypothesis that use of NSAIDs may delay or prevent the onset of PD.