Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis
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DOI：
10.1016/j.freeradbiomed.2010.06.003
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发表时间：
2010-09-01
影响因子：
7.4
通讯作者：
Monnier, Vincent M.
中科院分区：
文献类型：
--
作者：
Fan, Xingjun;Sell, David R.;Monnier, Vincent M.
比较了无氧(晶状体)和有氧(皮肤)环境对人体晶状体和胶原中晚期糖基化和氧化产物的影响。几乎所有的修饰都随着年龄的增长而增加，甲基乙二醛氢咪唑酮类化合物、羧甲基赖氨酸和羧乙基赖氨酸在晶状体中比皮肤中高几倍，与之相反，晶状体蛋白与5 mM抗坏血酸孵育后显著增加。果糖赖氨酸，葡萄糖烷交联物。乙二醛氢咪唑酮。金属催化氧化(烯丙氨酸)。而依赖H_2O_2的修饰(2-氨基脂肪酸和蛋氨酸亚磺酸)在皮肤中显著升高，但在两种组织中老化的晶状体中相对抑制，鸟氨酸是主要的修饰，暗示精氨酸残留物是体内美拉德反应的主要靶点糖尿病(这里主要是2型糖尿病)显著增加两个组织中的果糖-赖氨酸和葡萄糖苷(P
The effects of anaerobic (lens) vs aerobic (skin) environment on carbonyl and oxidant stress are compared using de novo and existing data on advanced glycation and oxidation products in human crystallins and collagen Almost all modifications increase with age Methylglyoxal hydroimidazolones, carboxymethyllysine, and carboxyethyllysine are severalfold higher in lens than in skin and markedly increase upon incubation of lens crystallins with 5 mM ascorbic acid In contrast. fructoselysine, glucosepane crosslinks. glyoxal hydroimidazolones. metal-catalyzed oxidation (allysine). and H2O2-dependent modifications (2-aminoapidic acid and methionine sulfoxide) are markedly elevated in skin, but relatively suppressed in the aging lens In both tissues ornithine is the dominant modification, implicating arginine residues as the principal target of the Maillard reaction in vivo Diabetes (here mostly type 2 studied) increases significantly fructose-lysine and glucosepane in both tissues (P