Major depression and medication adherence in elderly patients with coronary artery disease.
Major depression and medication adherence in elderly patients with coronary artery disease.
复制标题
老年冠状动脉疾病患者的重度抑郁和药物依从性。
DOI：
10.1037//0278-6133.14.1.88
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jaffe,AS
中科院分区：
文献类型：
--
作者：
Carney,RM;Freedland,KE;Eisen,SA;Rich,MW;Jaffe,AS
关于抑郁症对患有慢性内科疾病的老年患者坚持药物治疗方案的影响，人们知之甚少。依从性差可能解释了抑郁症患者的内科发病率和死亡率增加的原因。在55例以上的冠心病患者中，有10例符合《精神疾病诊断与统计手册》(第3版，修订版；美国精神病学协会，1987年)中的抑郁症诊断标准。所有患者都被开出了每天两次的小剂量阿司匹林方案，以降低他们患心肌梗死的风险。用一种不显眼的电子监测设备评估服药依从性3周。抑郁症患者坚持服药的天数为45%，而非抑郁症患者的坚持天数为69%(p<；02)。因此，在诊断出冠状动脉疾病后，重度抑郁症与预防性服用阿司匹林的依从性较差有关。
Little is known about the effects of depression on adherence to medical treatment regimens in older patients with chronic medical illnesses. Poor adherence may explain the increased risk of medical morbidity and mortality found in depressed medical patients. Ten of 55 patients over the age of 64 with coronary artery disease met the criteria for major depression from the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987). All patients were prescribed a twice-per-day regimen of low dose aspirin to reduce their risk for myocardial infarction. Medication adherence was assessed for 3 weeks by an unobtrusive electronic monitoring device. Depressed patients adhered to the regimen on 45% of days, but nondepressed patients, on 69%(p<. 02). Thus, major depression is associated with poor adherence to a regimen of prophylactic aspirin after the diagnosis of coronary artery disease.