Five-year point prevalence survey of healthcare-associated infections and antimicrobial use in a Japanese university hospital.
Five-year point prevalence survey of healthcare-associated infections and antimicrobial use in a Japanese university hospital.
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日本一所大学医院卫生保健相关感染和抗菌药物使用的五年点患病率调查
DOI：
10.1016/j.infpip.2021.100151
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发表时间：
2021-09
影响因子：
--
通讯作者：
Yagi T
中科院分区：
文献类型：
--
作者：
Morioka H;Iguchi M;Tetsuka N;Kinoshita F;Tomita Y;Kato D;Hirabayashi A;Matsumoto A;Oka K;Kato H;Inagaki T;Kato Y;Kitagawa K;Ichikawa K;Kouyama Y;Kawamura N;Toyodome Y;Adachi N;Ito Y;Yagi T
定期的点流行率调查(PPS)提供了一种方法，用于评估卫生保健相关感染(HAI)和抗菌药物使用随时间的变化。在名古屋大学医院(日本爱知)推行抗微生物管理方案之后，开展了为期五年的PPS研究，以突出任何流行病学变化。每年7月，在名古屋大学医院进行为期一天的PPS。使用标准的数据收集表格收集关于患者特征、医疗器械、活跃的人类免疫缺陷病毒感染和抗菌药物使用的数据。共纳入4339名患者。在五年的研究期间，患者的平均年龄为62岁，住院的平均持续时间为9天，9%的患者有HAI，35.2%的患者至少接受了一种抗菌药治疗。总体而言，406例HAI(95%可信区间，369-447)手术部位感染、肺炎和发热性中性粒细胞减少症发生率最高。肠杆菌属是最常见的病原菌(N=78，28.6%)，32.1%的患者对第三代头孢菌素耐药。美罗培南是HAIs最常用的抗菌药物。外科抗菌药物的预防发生了巨大的变化，持续时间更短，口服头孢菌素的使用也明显减少。然而，用于医学预防的抗菌药逐渐增加。这项为期五年的PPS研究显示了患者背景、人类免疫缺陷病毒和致病病原体的一致数据，并强调了国家抗菌素耐药性行动计划时代抗菌剂使用的变化。为了通过PPS描述日本医院的流行病学，应每年进行包括社区医院在内的多中心PPS。
Periodic point prevalence surveys (PPSs) provide a method for assessing changes in healthcare-associated infections (HAIs) and antimicrobial use over time. Following the introduction of an antimicrobial stewardship programme at Nagoya University Hospital (Aichi, Japan) a five-year PPS study was performed to highlight any epidemiological changes. One-day PPSs were performed annually in July at Nagoya University Hospital. Data on patient characteristics, medical devices, active HAIs and antimicrobial use were collected using a standard data-collection form. A total of 4339 patients were included. Over the five-year study period the median patient age was 62 years, median duration of hospital admission was nine days, 9% of patients had an HAI and 35.2% received at least one antimicrobial. Overall there were 406 HAIs (95% confidence interval, 369–447) with surgical site infection, pneumonia and febrile neutropenia occurring most frequently. Enterobacterales were the most common pathogens (N = 78, 28.6%) and 32.1% were third-generation cephalosporin-resistant. Meropenem was the most frequently prescribed antimicrobial for HAIs. Surgical antimicrobial prophylaxis changed drastically, with shorter durations and a marked reduction in oral cephalosporin use. However, antimicrobials for medical prophylaxis gradually increased. This five-year PPS study shows consistent data for patient background, HAIs and causative pathogens and highlights changes in antimicrobial use during the era of the National Action Plan on Antimicrobial Resistance. To describe the epidemiology of Japanese hospitals by PPS, multicentre PPSs including in community hospitals should be performed annually.
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影响因子：
7.5
作者：
Uda, Atsushi;Kimura, Takeshi;Miyara, Takayuki
通讯作者：
Miyara, Takayuki
影响因子：
34.3
作者：
Versporten, Ann;Zarb, Peter;Goossens, Herman
通讯作者：
Goossens, Herman
影响因子：
6.9
作者：
Morioka, H.;Nagao, M.;Yagi, T.
通讯作者：
Yagi, T.
影响因子：
4.2
作者：
Wu YL;Yang XY;Pan MS;Li RJ;Hu XQ;Zhang JJ;Yang LQ
通讯作者：
Yang LQ
DOI：
10.2807/1560-7917.es.2018.23.46.1800516
发表时间：
2018-11
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Suetens C;Latour K;Kärki T;Ricchizzi E;Kinross P;Moro ML;Jans B;Hopkins S;Hansen S;Lyytikäinen O;Reilly J;Deptula A;Zingg W;Plachouras D;Monnet DL;Healthcare-Associated Infections Prevalence Study Group
通讯作者：
Healthcare-Associated Infections Prevalence Study Group