Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population
Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population
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色氨酸羟化酶2基因与中国女性人群的重度抑郁症相关
DOI：
10.1016/j.jad.2011.04.037
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发表时间：
2011-10-01
影响因子：
6.6
通讯作者：
Yuan, Yonggui
中科院分区：
文献类型：
--
作者：
Shen, Xinhua;Wu, Yanfeng;Yuan, Yonggui
背景资料：以往的候选基因研究的重性抑郁症（MDD）提供了非决定性的证据关联的基因与强烈的生物学原理的MDD。本研究旨在探讨色氨酸羟化酶2基因与中国汉族人群抑郁症及其治疗反应的关系。从当地社区招募371名正常对照。通过聚合酶链反应对患者和正常对照进行TPH 2（rs 4290270和rs7305115）变异的基因分型。结果：MDD患者和正常对照组的等位基因频率和基因型频率无显著性差异。女性MDD患者A-A单倍型频率显著高于健康女性对照组（P < 0.05）。在单倍型和单标记分析中未发现与治疗反应的显著关联。局限性：本研究缺乏安慰剂对照，我们不能明确排除在反应组中的一些患者仅对安慰剂效应有反应的可能性。结论：结果表明，TPH 2基因可能对中国汉族人群MDD的易感性具有性别依赖性影响，但与其治疗反应无关。需要进一步的研究来复制我们观察到的关联。(C)2011 Elsevier B. V.保留所有权利。
Background: Previous candidate gene studies of major depressive disorder (MDD) have provided inconclusive evidence of association for genes with strong biological rationale for MDD. In this study, we aimed to investigate the association of tryptophan hydroxylase 2 gene with MDD and its treatment response in the Chinese Han population.Methods: Three hundred and sixty eight depressed patients who met DSM-IV criteria for major depressive disorder were recruited for the study. 371 normal controls were recruited from local community. Patients and normal controls were genotyped for TPH2 (rs4290270 and rs7305115) variants by polymerase chain reaction. Male and female subjects were analyzed separately.Results: No differences were found in the frequencies of the single alleles and genotypes of the tested polymorphisms between MDD patients and normal group. The frequency of the A-A haplotype was significantly higher in female MDD compared to healthy female controls (P < 0.05). No significant association with treatment response was discovered in haplotype and single-marker analysis.Limitations: This study lacks a placebo control and we cannot definitively exclude the possibility that some patients in the responder group responded to the placebo effect alone.Conclusion: The result suggests that TPH2 gene may have a gender dependent effect on susceptibility to MDD but not with its treatment response in Chinese Han population. Further studies are needed to replicate the association that we observed. (C) 2011 Elsevier B.V. All rights reserved.