Evidence for two types of brown adipose tissue in humans
Evidence for two types of brown adipose tissue in humans
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DOI：
10.1038/nm.3017
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发表时间：
2013-05-01
期刊：
影响因子：
82.9
通讯作者：
Enerback, Sven
中科院分区：
文献类型：
--
作者：
Lidell, Martin E.;Betz, Matthias J.;Enerback, Sven
以前观察到的棕色脂肪组织（BAT）在成年人锁骨上的仓库通常被认为是相当于小哺乳动物的肩胛间产热器官。这种观点最近受到了争议（1），其基础是证明该贮库由米色（也称为brite）棕色脂肪细胞组成，这是一种新发现的棕色脂肪细胞类型，不同于构成其他哺乳动物肩胛间产热器官的经典棕色脂肪细胞。高分辨率成像技术与组织学和生物化学分析的结合显示了人类婴儿中解剖学上可区分的肩胛间BAT（iBAT）储库的证据，该储库由经典的棕色脂肪细胞组成，这是一种迄今为止尚未显示存在于人类中的细胞类型。根据这些发现，我们得出结论，婴儿，类似于啮齿动物，有真正的iBAT产热器官组成的经典棕色脂肪细胞，是必不可少的生存的小型哺乳动物在寒冷的环境中。
The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed(1) on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.