Increased Ratio of Trunk-to-Appendicular Fat and Decreased Adiponectin: A Population-Based Study of School Children in Hamamatsu, Japan
Increased Ratio of Trunk-to-Appendicular Fat and Decreased Adiponectin: A Population-Based Study of School Children in Hamamatsu, Japan
复制标题
DOI：
10.1016/j.jocd.2015.10.004
复制
发表时间：
2017-01-01
影响因子：
2.5
通讯作者：
Iki, Masayuki
中科院分区：
文献类型：
--
作者：
Kouda, Katsuyasu;Nakamura, Harunobu;Iki, Masayuki
很少有流行病学研究探讨了内脏脂肪和皮下脂肪对血清脂联素水平的相对影响。据报道，躯干与四肢脂肪比是内脏脂肪比皮下脂肪更好的替代品。在本研究中，我们调查了脂联素和躯干与腹部脂肪比（TAR）之间的关系。资料来源人口为日本滨松市两所小学的所有五年级学生（799名学生）。在源人群中，我们分析了609名儿童（平均年龄：11.2岁）的横断面数据。通过双能X线吸收测定法评估TAR，并计算为躯干脂肪量除以四肢（手臂和腿部）脂肪量。在按总体脂的三分位数分层后，使用多元回归分析来检查调整潜在混杂因素后脂联素和TAR之间的关系。在最高三分位数的总体脂中，增加的TAR与降低的血清脂联素水平显著相关（p < 0.05）（男孩β = -0.32;女孩β = -0.31）。在第二个三分位数的总身体脂肪，TAR的女孩也表现出显着的负相关性与血清脂联素水平（β = -0.27）。这项基于人群的研究数据表明，躯干脂肪比例增加与相对超重儿童的脂联素降低相关，并且还表明，体脂体积正常的女孩遵循更集中的分布，脂联素降低。
Very few epidemiological studies have examined the relative impact of visceral fat and subcutaneous fat on serum adiponectin levels. Trunk-to-extremity fat ratio is reportedly a better surrogate for visceral fat than for subcutaneous fat. In the present study, we investigated the association between adiponectin and trunk-to-appendicular fat ratio (TAR) in a school population. The source population was all fifth graders (799 pupils) enrolled in the 2 elementary schools in Hamamatsu, Japan. Of the source population, we analyzed cross-sectional data from 609 children (mean age: 11.2 yr). TAR was evaluated by dual-energy X-ray absorptiometry and calculated as trunk fat mass divided by appendicular (arms and legs) fat mass. After stratification by tertiles of total body fat, multiple regression analysis was used to examine the relationships between adiponectin and TAR adjusted for potential confounding factors. In the highest tertile of total body fat, increasing TARs were significantly (p < 0.05) associated with decreasing serum adiponectin levels after stratification by total body fat (beta = -0.32 in boys; beta = -0.31 in girls). In the second tertile of total body fat, TAR in girls also showed significant inverse relationships with serum adiponectin levels (beta = -0.27). Data from this population-based study demonstrated that an increased proportion of trunk fat is associated with decreased adiponectin in relatively overweight children, and also demonstrated that girls with a normal volume of body fat that follows a more centralized distribution show decreased adiponectin.