Markers of periodontal infection and preterm birth
Markers of periodontal infection and preterm birth
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DOI：
10.1016/j.ajog.2004.07.018
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发表时间：
2005-02-01
影响因子：
9.8
通讯作者：
Papapanou, PN
中科院分区：
文献类型：
--
作者：
Jarjoura, K;Devine, PC;Papapanou, PN
目的：探讨牙周炎与早产(PTB)的临床、微生物学和血清学指标之间的关系。研究设计：将单胎妊娠在37周前分娩的孕妇(83例)与足月分娩对照组(120例)比较。产后48小时内进行牙周检查，采集牙菌斑和血样。对口腔细菌的微生物水平和母体免疫球蛋白G滴度进行分析。结果：病例的平均附着丧失(1.7vs1.5 mm，P=.003)和牙周炎的患病率(30.1%vs17.5%，P=.027)较高。两组之间没有检测到微生物或血清抗体水平的差异。Logistic回归分析显示，肺结核与依恋丧失相关(调整后优势比：2.75，95%CI：1.01~7.54)。线性回归表明，附着丧失与低出生体重之间存在显著的相关性(P=.04)。结论：数据支持牙周炎与肺结核和低出生体重独立相关的观点。(C)2005 Elsevier Inc.保留所有权利。
Objective: This study was undertaken to explore the relationship between clinical, microbiologic, and serologic markers of periodontitis and preterm birth (PTB).Study design: We compared women with a singleton gestation giving birth before the 37th week (cases, n = 83) with term delivery controls (n = 120). Periodontal examination and collection of dental plaque and blood samples were performed within 48 hours after delivery. Microbial levels and maternal immunoglobulin G titers to oral bacteria were analyzed. Multivariate regression models were fitted controlling for common covariates.Results: Cases showed greater mean attachment loss (1.7 vs 1.5 mm, P = .003) and higher prevalence of periodontitis (30.1% vs 17.5%, P = .027). No differences in microbial or serum antibody levels were detected between the groups. Logistic regression revealed that PTB was associated with attachment loss (adjusted odds ratio: 2.75, 95% CI: 1.01-7.54). Linear regression indicated a significant (P = .04) association between attachment loss and low birth weight (LBW).Conclusion: The data support the notion that periodontitis is independently associated with PTB and LBW. (C) 2005 Elsevier Inc. All rights reserved.