Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression.
Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression.
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DOI：
10.1002/mrm.25277
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发表时间：
2015-04
影响因子：
3.3
通讯作者：
Chen, Zhong
中科院分区：
文献类型：
--
作者：
Lu, Jianhua;Zhou, Jinyuan;Cai, Congbo;Cai, Shuhui;Chen, Zhong
关键词：
目的探讨7T时脑内核磁共振增强(NOE)成像信号的特点。对6只健康Wistar大鼠、6只健康Wistar大鼠和6只C6胶质瘤Wistar大鼠的新鲜鸡蛋和6只C6胶质瘤大鼠进行了CEST-MRI和CEST-MRS序列(饱和持续时间3 S，幂1.47μT)的扫描。CEST数据以0.5ppm的步长在相对于水共振的−6ppm至+6ppm的偏移范围内采集。在CEST-MRS序列中，水的信号没有被其他质子干扰，可以观察到真实的NOE信号。使用无脂抑制的CEST-MRI序列，在含脂区域(蛋黄、头皮甚至白质)观察到假NOE成像信号。随着脂质的抑制，这些假NOE信号几乎(但不完全)被消除。蛋黄结果表明，NOE到烯烃质子的存在与水的信号重叠。体内实验表明，肿瘤中的酰胺质子转移信号较大，而正常脑白质中的NOE信号较大。使用MRS序列可以检测到真实的NOE信号，并且使用MRI序列可以观察到相当大的伪NOE成像信号。
To investigate the characteristics of nuclear Overhauser enhancement (NOE) imaging signals in the brain at 7T. Fresh hen eggs, as well as six healthy, and six C6 glioma-bearing Wistar rats were scanned using CEST-MRI and CEST-MRS sequences (saturation duration 3 s, power 1.47 μT) with and without lipid suppression. CEST data were acquired over an offset range of −6 to +6 ppm relative to the water resonance in 0.5 ppm steps. The water signals were not disrupted by other protons during the CEST-MRS sequences, and true NOE signals could be observed. Using the CEST-MRI sequence without lipid suppression, pseudo NOE imaging signals were observed in the lipid-containing regions (egg yolk, scalp, and even white matter). These pseudo NOE signals were almost (but incompletely) removed with the lipid suppression. Egg yolk results indicated the presence of the NOE to olefinic protons overlapping with the water signal. In vivo experiments showed that the amide proton transfer signal was larger in the tumor, while the NOE signal was larger in the normal white matter. True NOE signals can be detected using MRS sequences, and considerable pseudo NOE imaging signals may be observed using MRI sequences.
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影响因子：
2.9
作者：
Xu, Junzhong;Zaiss, Moritz;Zu, Zhongliang;Li, Hua;Xie, Jingping;Gochberg, Daniel F.;Bachert, Peter;Gore, John C.
通讯作者：
Gore, John C.
影响因子：
2.9
作者：
Tietze, Anna;Blicher, Jakob;Mikkelsen, Irene Klaerke;Ostergaard, Leif;Strother, Megan K.;Smith, Seth A.;Donahue, Manus J.
通讯作者：
Donahue, Manus J.
影响因子：
3.3
作者：
Liu, Guanshu;Li, Yuguo;Pagel, Mark D.
通讯作者：
Pagel, Mark D.
影响因子：
2.2
作者：
Ward, KM;Aletras, AH;Balaban, RS
通讯作者：
Balaban, RS
影响因子：
5.7
作者：
Jin, Tao;Wang, Ping;Zong, Xiaopeng;Kim, Seong-Gi
通讯作者：
Kim, Seong-Gi