Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.
Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.
复制标题
福克斯角膜营养不良听力测定模式的初步研究。
DOI：
10.1044/2018_jslhr-h-18-0088
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Gottsch,JohnD
中科院分区：
文献类型：
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作者：
Reed,NicholasS;Deal,JenniferA;Huddle,MatthewG;Betz,JoshuaF;Bailey,BethanyE;McGlumphy,ElyseJ;Eghrari,AllenO;Riazuddin,SAmer;Lin,FrankR;Gottsch,JohnD
虽然Fuchs角膜营养不良（FCD）被认为是一种眼病，但少数研究已经确定了FCD和听力损失的相关基因。FCD是否与听力损失有关是未知的。MethodThis是一项病例对照研究，比较纯音测听听力阈值在180例FCD患者从医院为基础的眼科诊所与2,575人口为基础的控制从全国代表性的调查，全国健康和营养检查调查（从2005-06和2009-10周期）。广义估计方程用于比较两组中的平均听力较好的耳阈值，调整了年龄、性别、种族、结果FCD患者的听阈高于对照组，（听力较差）在较低的频率（0.5 kHz时的平均差异= 3.49 dB HL）和较低的听阈（更好的听力）在更高的频率（4 kHz下的差异= −4.25 dB HL）与基于人群的对照组相比。结论在第一项使用客观测量听力的研究中，与人群对照组相比，FCD与低频听阈较差和高频听阈较好相关。需要进一步的研究来描述这种关系。
PurposeAlthough Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown.MethodThis is a case–control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10). Generalized estimating equations were used to compare mean better-hearing ear thresholds in the 2 groups adjusted for age, sex, race, and noise exposure.ResultsPatients with FCD had higher hearing thresholds (worse hearing) in lower frequencies (mean difference at 0.5 kHz = 3.49 dB HL) and lower hearing thresholds (better hearing) in higher frequencies (difference at 4 kHz = −4.25 dB HL) compared with population-based controls.ConclusionIn the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship.