Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review.
Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review.
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DOI：
10.1155/2015/572951
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发表时间：
2015
影响因子：
0.6
通讯作者：
Sugimura H
中科院分区：
文献类型：
--
作者：
Kuroda S;Suzuki S;Kurita A;Muraki M;Aoshima Y;Tanioka F;Sugimura H
背景。睾丸核蛋白中线癌（NMC）是一种非常罕见的恶性肿瘤。在超过三分之二的NMC病例中，NUT与BRD4或BRD3融合已被记录；其他变种很少见。NMC本身的细胞学文献很少，变异的NMC从未报道过。例演示。一名36岁的女性因快速发展的肺部肿瘤转移到乳房和骨骼而入院。根据免疫组织化学和遗传分析，我们最近报道了该患者为首例肺变异型NMC携带NSD3-NUT融合的病例。细胞学资料可用于本综述。高度细胞涂片显示单形细胞的非内聚模式，直径为小淋巴细胞的2-2.5倍，核圆至卵圆形，核轮廓略不规则，核仁不同程度地突出，细胞质较少，可识别有丝分裂象。偶见分层灶和明显的珍珠形成，包括角化不良细胞。坏死背景包括裸核、核纤维碎片、凋亡细胞和吞噬核纤维碎片的巨噬细胞；注意到核粉碎。结论。本文首次报道了肺NMC的细胞学特征。
Background. Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive malignancy. In more than two-thirds of these NMC cases, a fusion between NUT and BRD4 or BRD3 has been documented; other variants are rare. The cytology of NMC itself has been sparsely documented and that of variant NMC has never been reported. Case Presentation. A 36-year-old woman was admitted because of a rapidly progressing lung tumor with metastases to the breast and bone. We recently reported this patient as the first case of a variant NMC of the lung harboring an NSD3-NUT fusion, based on immunohistochemical and genetic analyses. Cytological material was available for the present review. A highly cellular smear contained a predominantly noncohesive pattern of monomorphic cells with diameters 2–2.5 times greater than those of small lymphocytes, with a round-to-oval nucleus, slightly irregular nuclear contours, variably prominent nucleoli, scant cytoplasm, and identifiable mitotic figures. Foci of stratification and overt pearl formation, including a dyskeratocyte, were occasionally observed. The necrotic background contained naked nuclei, karyorrhectic debris, apoptotic cells, and macrophages phagocytizing karyorrhectic debris; nuclear crushing was noted. Conclusion. The cytological features of a variant NMC of the lung are described for the first time.