Enhancing cognitive performance with repetitive transcranial magnetic stimulation at human individual alpha frequency
Enhancing cognitive performance with repetitive transcranial magnetic stimulation at human individual alpha frequency
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DOI：
10.1046/j.1460-9568.2003.02517.x
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发表时间：
2003-03-01
影响因子：
3.4
通讯作者：
Gerloff, C
中科院分区：
文献类型：
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作者：
Klimesch, W;Sauseng, P;Gerloff, C
我们应用快速重复经颅磁刺激（rTMS）在个人α频率（IAF），以改善认知性能的影响α去兴奋的动态。先前的研究表明，在任务之前的参考区间中的大的上α功率与任务期间的大的上α功率抑制和良好的性能都相关。在这里，我们测试的假设，rTMS在个人上限α频率（IAF + 1 Hz）可以提高α功率在参考区间，从而可以提高任务性能。将TMS重复传递到内侧额叶（Fz）和右侧顶叶（P6）皮质，并作为假手术条件，线圈倾斜90度（P6位置）。在心理旋转任务的行为效果进行了评估。进一步的对照条件是在较低IAF（IAF - 3 Hz）和20 Hz下的rTMS。结果表明，在IAF + 1 Hz的rTMS可以提高任务的性能，并伴随着，任务相关的α去极化的程度。这进一步证明了α波段振荡神经元活动与认知表现的功能相关性。
We applied rapid-rate repetitive transcranial magnetic stimulation (rTMS) at individual alpha frequency (IAF) to improve cognitive performance by influencing the dynamics of alpha desynchronization. Previous research indicates that a large upper alpha power in a reference interval preceding a task is related to both large suppression of upper alpha power during the task and good performance. Here, we tested the hypothesis that rTMS at individual upper alpha frequency (IAF + 1 Hz) can enhance alpha power in the reference interval, and can thus improve task performance. Repetitive TMS was delivered to the mesial frontal (Fz) and right parietal (P6) cortex, and as sham condition with 90degrees-tilted coil (P6 position). The behavioural effect was assessed in a mental rotation task. Further control conditions were rTMS at a lower IAF (IAF - 3 Hz) and at 20 Hz. The results indicate that rTMS at IAF + 1 Hz can enhance task performance and, concomitantly, the extent of task-related alpha desynchronization. This provides further evidence for the functional relevance of oscillatory neuronal activity in the alpha band for the implementation of cognitive performance.