Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.
Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.
复制标题
脂肪酸酰胺水解酶的杂环亚砜和砜抑制剂。
DOI：
10.1016/j.bmcl.2004.10.025
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发表时间：
2005
影响因子：
2.7
通讯作者：
Boger,DaleL
中科院分区：
文献类型：
--
作者：
Du,Wu;Hardouin,Christophe;Cheng,Heng;Hwang,Inkyu;Boger,DaleL
制备了一系列新的杂环亚砜和砜，并将其作为脂肪酸酰胺水解酶（FAAH）的潜在抑制剂进行了研究，FAAH是负责神经调节脂肪酸酰胺（包括花生四烯酸酰胺和油酰胺）失活的酶。
A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.