Neuro-QOL Brief measures of health-related quality of life for clinical research in neurology
Neuro-QOL Brief measures of health-related quality of life for clinical research in neurology
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DOI：
10.1212/wnl.0b013e318258f744
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发表时间：
2012-06-01
期刊：
影响因子：
9.9
通讯作者：
Moy, C.
中科院分区：
文献类型：
--
作者：
Cella, D.;Lai, J-S.;Moy, C.
目的：为了解决需要简短的，可靠的，有效的，和标准化的生活质量（QOL）评估适用于neurologic conditions.Methods：绘图从较大的校准项目银行，我们制定了简短的措施（8-9个项目）的13个不同的生活质量领域的身体，精神和社会健康，并评估其有效性和可靠性。在简表开发期间使用了三个样本：一般人群（基于互联网，n = 2，113）;临床小组（基于互联网，n = 553）;和临床门诊患者（基于诊所，n = 581）。结果：13种简易量表的内部一致性系数（Cronbach α）在0.85 ~ 0.97之间。简表和全长试题库得分之间的相关性范围为0.88 - 0.99（从库中删除常见项目后为0.82-0.96）。在线受访者被问及他们是否患有19种不同的慢性健康状况中的任何一种，以及这些报告的状况是否干扰了正常运作的能力。所有简短的形式，在身体，精神和社会健康，能够区分谁报告没有健康状况的人从那些谁报告1-2或3或更多。此外，与那些报告健康状况但不受健康状况限制的人相比，那些承认自己受到健康状况限制的人在所有13个领域的得分都更差。这13个简单的自我测量报告的生活质量是可靠的，并显示出并行有效性的初步证据，因为它们根据报告的健康状况的数量以及这些报告的状况是否妨碍正常功能。神经病学（R）2012;78：1860-1867
Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions.Methods: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n = 581). All short forms are expressed as T scores with a mean of 50 and SD of 10.Results: Internal consistency (Cronbach alpha) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82-0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them.Conclusion: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function. Neurology (R) 2012;78:1860-1867