EFFECTS OF TRAINING IN NORMOXIA AND NORMOBARIC HYPOXIA ON HUMAN MUSCLE ULTRASTRUCTURE
EFFECTS OF TRAINING IN NORMOXIA AND NORMOBARIC HYPOXIA ON HUMAN MUSCLE ULTRASTRUCTURE
复制标题
DOI：
10.1007/bf00374176
复制
发表时间：
1993-11-01
影响因子：
4.5
通讯作者：
GEYSSANT, A
中科院分区：
文献类型：
--
作者：
DESPLANCHES, D;HOPPELER, H;GEYSSANT, A
研究了骨骼肌对常氧和重度常压低氧训练的适应性反应。第一组5名男性受试者在常氧条件下进行为期3周的自行车训练(每天2小时，每周6天)(对照训练)。第二组5名受试者在低氧环境中进行训练，氧分压从12.7%逐渐下降到10.0%(低氧训练，Hyp T)。14个月后，这些受试者在相同的绝对功率下进行常氧训练(常氧训练，Nor T)。测定常氧和低氧条件下的最大耗氧量(VO2 Max)。对股外侧肌活检标本进行纤维大小、毛细血管和超微结构成分分析。Nor T对肌肉组织和最大摄氧量无明显影响。ConT使总线粒体和脂类的体密度分别增加36%和135%(P<；0.05)。Hyp-T可使低氧时的最大摄氧量增加10%(P<；0.05)。Hyp T组平均纤维横截面积、线粒体体积密度和毛细血管纤维比分别增加10%、42%和13%(P<；0.05)。这些结果表明，在相同的相对负荷下，常氧和低氧训练对肌肉组织的影响相似，但不完全相同。如果在与严重缺氧相同的绝对工作量下进行常氧训练，则没有观察到显著的效果。
The adaptive response of skeletal muscle to training in normoxia and in severe normobaric hypoxia was studied. The first group of five male subjects trained for 3 weeks on a bicycle (2 h/day, 6 days/week) in normoxia (Control training, Con T). A second group of five subjects trained in an ambient FIO2 decreasing progressively from 12.7% to a final level of 10.0% (hypoxic training, Hyp T). Fourteen months later, these subjects trained in normoxia at the same absolute power (normoxic training, Nor T). Peak oxygen consumption (VO2 max) was measured in normoxic and hypoxic conditions. Biopsies from the vastus lateralis muscle were analysed for fibre size, capillary and ultrastructural composition. Nor T had no effect on muscle tissue or VO2 max. Con T increased volume density of total mitochondria and lipids by 36 and 135% respectively (P < 0.05). Hyp T induced a 10% increase (P < 0.05) in peak VO2 max measured in hypoxia. Mean fibre cross-sectional area, interfibrillar mitochondrial volume density and capillary-to-fibre ratio were increased (P < 0.05) by 10, 42 and 13% respectively in the Hyp T group. These results suggest that training at the same relative workload in normoxia and hypoxia have similar, but not identical, effects on muscle tissue. If training in normoxia is carried out at the same absolute workload as in severe hypoxia, no significant effects are observed.