Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults
Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults
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DOI：
10.1038/hr.2010.171
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发表时间：
2010-12-01
影响因子：
5.4
通讯作者：
Node, Koichi
中科院分区：
文献类型：
--
作者：
Yakushiji, Yusuke;Nanri, Yusuke;Node, Koichi
肾功能障碍，如慢性肾脏病(CKD)与脑形态的关系已引起越来越多的关注，但肾功能障碍与脑萎缩之间的关系尚未确定。本研究的目的是阐明肾功能与相当程度的脑萎缩之间的关系。共有610名连续接受大脑健康筛查测试的无神经障碍的日本成年人进行了前瞻性研究。使用1.5T扫描仪进行磁共振成像。使用计算机辅助处理系统，计算大脑萎缩的百分比(%大脑萎缩)作为大脑萎缩的指标。萎缩被定义为<gt；2S.D.S低于平均%的大脑萎缩。在日本，肾小球滤过率(GFR)是使用修订后的公式估计的，根据血清肌酐估算GFR。肾功能变量包括GFR值和GFR受试者的患病率
The relationship between kidney dysfunction, such as chronic kidney disease (CKD), and brain morphology has attracted increasing attention, but the association between kidney dysfunction and cerebral atrophy has yet to be determined. The purpose of this study was to clarify the relationship between kidney function and a substantial degree of cerebral atrophy. A total of 610 consecutive Japanese adults without neurological disorders who had undergone health screening tests of the brain were studied prospectively. Magnetic resonance imaging was performed using a 1.5-T scanner. Using a computer-assisted processing system, the percentage of cerebrum atrophy (%Cerebrum atrophy) was calculated as an index of cerebral atrophy. Atrophy was defined as >2 s.d.s below the mean %Cerebrum atrophy. The glomerular filtration rate (GFR) was estimated using the revised equations for estimated GFR from serum creatinine in Japan. Kidney function variables included the GFR value and the prevalence of subjects with GFR