Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation.
Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation.
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DOI：
10.1016/j.expneurol.2016.12.005
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发表时间：
2017-03
影响因子：
5.3
通讯作者：
Hays SA
中科院分区：
文献类型：
--
作者：
Hulsey DR;Riley JR;Loerwald KW;Rennaker RL 2nd;Kilgard MP;Hays SA
迷走神经刺激（VNS）已成为治疗各种神经系统疾病的疗法，包括癫痫、抑郁症、中风和耳鸣。蓝斑（LC）中神经元的激活被认为介导VNS在中枢神经系统中的许多作用。尽管LC的重要性，有一个缺乏直接的证据表征神经活动的VNS。对在一系列刺激参数范围内由VNS诱发的脑活动的详细理解可以指导用于治疗用途的刺激方案的选择。在这项研究中，我们记录了LC和中脑三叉神经核（Me5）的神经活动，在很宽的范围内的电流幅度，脉冲频率，列车持续时间，列车间隔和脉冲宽度的VNS响应。在0.1 mA时，短暂的0.5 s VNS序列驱动LC神经元的快速相位放电。更高的电流强度和更长的脉冲宽度驱动LC激发速率的更大增加。改变脉冲频率实质上影响相位LC活性的定时，但不影响总量。VNS驱动Me5中的脉冲锁定神经活动，电流水平高于1.2 mA。这些结果提供了深入了解VNS诱发的阶段性神经活动在多个神经结构，并可能是有用的指导VNS参数的选择，以提高临床疗效。
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of neurons in the locus coeruleus (LC) is believed to mediate many of the effects of VNS in the central nervous system. Despite the importance of the LC, there is a dearth of direct evidence characterizing neural activity in response to VNS. A detailed understanding of the brain activity evoked by VNS across a range of stimulation parameters may guide selection of stimulation regimens for therapeutic use. In this study, we recorded neural activity in the LC and the mesencephalic trigeminal nucleus (Me5) in response to VNS over a broad range of current amplitudes, pulse frequencies, train durations, inter-train intervals, and pulse widths. Brief 0.5 s trains of VNS drive rapid, phasic firing of LC neurons at 0.1 mA. Higher current intensities and longer pulse widths drive greater increases in LC firing rate. Varying the pulse frequency substantially affects the timing, but not the total amount, of phasic LC activity. VNS drives pulse-locked neural activity in the Me5 at current levels above 1.2 mA. These results provide insight into VNS-evoked phasic neural activity in multiple neural structures and may be useful in guiding the selection of VNS parameters to enhance clinical efficacy.