Applications and toxicity of silver nanoparticles: a recent review.
Applications and toxicity of silver nanoparticles: a recent review.
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DOI：
10.2174/1568026615666150414142209
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发表时间：
2015-07
影响因子：
3.4
通讯作者：
Ș. Marin;G. Vlăsceanu;R. Țiplea;Ioana Raluca Bucur;Mădălina Lemnaru;M. Marin;A. Grumezescu
中科院分区：
文献类型：
--
作者：
Ș. Marin;G. Vlăsceanu;R. Țiplea;Ioana Raluca Bucur;Mădălina Lemnaru;M. Marin;A. Grumezescu
银纳米颗粒(AgNPs)具有一致的柔性，在生物医学及相关领域具有广泛的应用前景。多年来，银纳米颗粒已经进行了无数的体外和体内测试，以提供关于它们对活组织和生物的毒性行为的信息。研究人员表明，AgNPs对许多细菌种类都有很高的抗菌效果，包括大肠杆菌、奈瑟菌淋病、沙眼衣原体和病毒。由于银纳米粒子具有新颖的性质，将其引入纺织纤维和伤口敷料等不同材料中可以扩大其在生物医学领域的应用，同时抑制感染和生物膜的发展。在贵金属纳米粒子中，AgNPs具有合成路线简单、形貌可调、比表面积大、胞内传输系统、较大的等离子体野面积等一系列特点，是理想的生物传感器、催化剂或光控传输系统。在生物工程中，银纳米颗粒被认为是组织再生的潜在理想的基因传递系统。远程触发检测和释放银纳米颗粒的生物活性化合物也证明了它们在法医学中的相关性。作者报道了有关AgNPs的毒性及其在抗菌活性和用于基因治疗的生物传感器方面的应用的最新综述。
Silver nanoparticles (AgNPs) exhibit a consistent amount of flexible properties which endorse them for a larger spectrum of applications in biomedicine and related fields. Over the years, silver nanoparticles have been subjected to numerous in vitro and in vivo tests to provide information about their toxic behavior towards living tissues and organisms. Researchers showed that AgNPs have high antimicrobial efficacy against many bacteria species including Escherichia coli, Neisseria gonorrhea, Chlamydia trachomatis and also viruses. Due to their novel properties, the incorporation of silver nanoparticles into different materials like textile fibers and wound dressings can extend their utility on the biomedical field while inhibiting infections and biofilm development. Among the noble metal nanoparticles, AgNPs present a series of features like simple synthesis routes, adequate and tunable morphology, and high surface to volume ratio, intracellular delivery system, a large plasmon field area recommending them as ideal biosensors, catalysts or photo-controlled delivery systems. In bioengineering, silver nanoparticles are considered potentially ideal gene delivery systems for tissue regeneration. The remote triggered detection and release of bioactive compounds of silver nanoparticles has proved their relevance also in forensic sciences. The authors report an up to date review related to the toxicity of AgNPs and their applications in antimicrobial activity and biosensors for gene therapy.