Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats
Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats
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DOI：
10.1093/brain/awh160
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发表时间：
2004-06-01
期刊：
影响因子：
14.5
通讯作者：
Basso, DM
中科院分区：
文献类型：
--
作者：
Hutchinson, KJ;Gómez-Pinilla, F;Basso, DM
脊髓损伤(SCI)会导致丧失能力的神经病理性疼痛，表现为痛觉异常--这是对正常的非伤害性刺激的痛苦反应。不幸的是，这些感觉变化的潜在机制还没有被很好地理解，有效的治疗超常疼痛的方法也被证明是难以捉摸的。我们研究了体育锻炼是否可以通过促进脊髓和外周神经营养因子的表达来改善实验性脊髓损伤后的感觉功能，神经营养因子调节突触传递和功能。中度脊髓挫伤的雌性大鼠参加跑台训练、游泳训练、站立训练或未训练。运动训练从术后4d开始，每天20~25min，每周5天，共7周。用不同屈曲力的von Frey毛发对足底后爪的弯曲力测量，未训练组在脊髓损伤后3周出现痛觉过敏。5周后，跑台训练改善了痛觉异常，恢复了正常感觉。游泳训练有短暂的有益效果，但在7周后又出现了超常疼痛。站立训练没有效果。跑步机训练后痛觉过敏的缓解与腰髓和比目鱼肌中脑源性神经营养因子(BDNF)的正常mRNA水平有关。没有其他运动范式在中枢和外周恢复脑源性神经营养因子。痛觉异常的较大恢复与中枢和外周脑源性神经营养因子水平的正常化程度显著相关。这些发现表明，有节奏的负重运动可能是对抗脊髓损伤引起的痛觉异常的有效干预措施。
Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia-a painful response to normally non-noxious stimuli. Unfortunately, the underlying mechanisms of these sensory changes are not well understood, and effective treatments for allodynia have proven elusive. We examined whether physical exercise can improve sensory function after experimental SCI by promoting neurotrophin expression in the spinal cord and periphery, which modulates synaptic transmission and function. Female rats with moderate spinal cord contusion participated in treadmill training, swim training, stand training or were untrained. Exercise training began 4 days post surgery, lasted 20-25 min per day, 5 days a week for 7 weeks. Allodynia, as measured using von Frey hairs of different bending forces to the plantar hind paw, developed in the untrained group 3 weeks after SCI. Treadmill training ameliorated allodynia and restored normal sensation by 5 weeks. Swim training had a transient beneficial effect, but allodynia returned by 7 weeks. Stand training had no effect. Resolution of allodynia after treadmill training was associated with normal mRNA levels of brain-derived neurotrophic factor (BDNF) in both the lumbar spinal cord and soleus muscle. No other exercise paradigm restored BDNF centrally and peripherally. Greater recovery from allodynia correlated significantly with the degree of normalization of central and peripheral BDNF levels. These findings suggest that rhythmic, weight-bearing exercise may be an effective intervention to counter SCI-induced allodynia.