Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis
Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis
复制标题
血清 Clara 细胞蛋白 16 和表面活性剂蛋白 D 在矽肺早期诊断和进展中的作用
DOI：
10.1097/jom.0b013e318124a927
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发表时间：
2007
影响因子：
3.2
通讯作者：
Xian
中科院分区：
文献类型：
--
作者：
Shi;Ping Liu;Mao;Lei Chen;Yang Guo;Ran;Z. Tu;Xian
目的：探讨Clara细胞蛋白16（CC 16）和表面活性蛋白D（SP-D）作为血清生物标志物在矽肺早期诊断和发病机制中的作用。方法：30名健康志愿者、30名矽尘作业工人、30名疑似矽肺和Ⅰ期矽肺工人。采用酶联免疫吸附法测定血清CC 16和SP-D浓度。结果如下：与对照组相比，矽尘作业工人血清CC 16浓度降低，而SP-D浓度升高，这一趋势在0+期和I期组中更为明显。判别分析结果表明，将组成员划分为对照组、0期、0+期和I期的准确率分别为86.7%、46.7%、66.7%和70%，总分类准确率为67.5%。结论：血清CC 16和SP-D可作为矽肺早期诊断的生物标志物，血清SP-D浓度可能与矽肺发病有关。
Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis. Methods: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay. Results: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0+ and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0+, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%. Conclusion: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
表面活性蛋白 D。二氧化硅诱导的肺脂蛋白沉积症中积累增加。
DOI：
--
发表时间：
1991
期刊：
The American journal of pathology
影响因子：
--
作者：
Crouch,E;Persson,A;Chang,D;Parghi,D
通讯作者：
Parghi,D
DOI：
10.1172/jci15293
发表时间：
2002-03
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
F. McCormack;J. Whitsett
通讯作者：
F. McCormack;J. Whitsett