Molecular cloning and characterization of a novel cbl-family gene, cbl-c
Molecular cloning and characterization of a novel cbl-family gene, cbl-c
复制标题
DOI：
10.1016/s0378-1119(99)00356-x
复制
发表时间：
1999-10-18
期刊：
影响因子：
3.5
通讯作者：
Yamamoto, T
中科院分区：
文献类型：
--
作者：
Kim, M;Tezuka, T;Yamamoto, T
We have cloned a novel gene, cbl-c, of mammalian cbl-family. The cbl-e gene is predicted to encode a protein of 52 kDa that has a phosphotyrosine-binding domain, a RING finger and a, proline-rich region. Cbl-c shows 50% homology to the aminoterminal sequences of Cbl and Cbl-b, but a sequence corresponding to the carboxy-terminal half of Cbl and Cbl-b is largely missing in Cbl-c. The expression of cbl-e mRNA is distinct from that of cbr and cbl-b mRNAs, being high in the colon and small intestine, but undetectable in brain and lymphoid tissues. The cbl-e gene is mapped in 19q13.2-13.3. Finally, the 52 kDa Cbl-c protein binds to the EGF receptor and Fyn tyrosine kinase. We conclude that Cbl-c is a novel Cbl-family adaptor protein that would regulate intracellular signaling mediated by various tyrosine kinases. (C) 1999 Elsevier Science B.V. All rights reserved.
