SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents
SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents
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DOI：
10.4161/cbt.6.12.4971
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发表时间：
2007-12-01
影响因子：
3.6
通讯作者：
Mabjeesh, Nicola J.
中科院分区：
文献类型：
--
作者：
Arnir, Sharon;Mabjeesh, Nicola J.
SEPT9是哺乳动物SEPTIN家族成员。越来越多的证据表明SEPT9在癌症中起作用。蛋白产物SEPT9_V1与微管结合并与缺氧诱导因子(HIF)-1α相互作用，HIF-1α是关键转录因子HIF-1的调节亚基。HIF-1的转录活性完全依赖于完整的微管。我们验证了SEPT9_V1对微管介导的HIF-1抑制剂具有耐药性的假设。SEPT9_V1蛋白表达与多种癌细胞对2-甲氧基雌二醇和紫杉醇的敏感性密切相关。我们的结果表明，SEPT9_V1可以作为对微管干扰剂的治疗抗性的生物标志物。
SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1 alpha, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.