A nomogram for predicting depression in patients with hepatocellular carcinoma: an observational cross-sectional study
A nomogram for predicting depression in patients with hepatocellular carcinoma: an observational cross-sectional study
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DOI：
10.1080/13651501.2019.1619777
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发表时间：
2019-05-22
影响因子：
3
通讯作者：
Chen, Li
中科院分区：
文献类型：
--
作者：
Jia, Yong;Zhang, Wenlei;Chen, Li
目的：抑郁症在肝细胞癌患者中很常见。预测抑郁症对于治疗肝细胞癌患者至关重要。本研究的目的是建立一个全面的视觉预测列线图，用于计算肝细胞癌患者抑郁的概率估计。方法：纳入 269 例诊断为肝细胞癌的患者。人口统计和临床信息是从医疗记录中收集的。根据多元回归分析的结果构建列线图。使用辨别和校准来评估其性能。使用决策曲线分析来评估其临床效用。结果：共发现 134 例（49.82%）肝细胞癌患者患有抑郁症。列线图中包括教育水平、社会支持、疼痛强度、向患者披露癌症诊断信息以及 Child-Pugh 等级。 AUC 为 0.828，表明区分度良好。列线图显示的校准曲线与理想预测略有偏差，并且在决策曲线分析中具有较高的净效益。结论：我们提出了一种用于个体化预测肝细胞癌患者抑郁情绪的列线图，具有令人满意的性能和临床实用性。要点/亮点建立了直观、全面、方便的肝细胞癌患者抑郁预测列线图。所提出的列线图显示出令人满意的效度、区分度和临床实用性，表明预测抑郁症具有良好的性能。 足以保证纳入列线图中的信息和预测包括患者教育水平、疼痛强度、社会支持、向患者披露肝细胞癌诊断信息和 Child-Pugh 分级。
Objectives: Depression is common in hepatocellular carcinoma patients. Predicting depression is critical for managing hepatocellular carcinoma patients. The aim of this study was to establish a comprehensive visual predictive nomogram for calculating a probabilistic estimate of depression in hepatocellular carcinoma patients. Methods: Two-hundred and sixty-nine patients diagnosed with hepatocellular carcinoma were included. The demographic and clinical information was collected from medical records. A nomogram was constructed based on the results of a multivariate regression analysis. Discrimination and calibration were used to assess its performance. A decision curve analysis was used to assess its clinical utility. Results: One hundred and thirty-four (49.82%) hepatocellular carcinoma patients with depression were identified. The education level, social support, pain intensity, disclosure of the cancer diagnosis to the patient and Child-Pugh class were included in the nomogram. The AUC was 0.828, indicating good discrimination. The nomogram demonstrated calibration curves with slight deviation from the ideal predictions and a high net benefit in the decision curve analysis. Conclusions: We proposed a nomogram for the individualised prediction of depression in hepatocellular carcinoma patients with satisfactory performance and clinical utility.KEY POINTS/HIGHLIGHTSA visual, comprehensive and convenient nomogram was established for the prediction of depression in patients with hepatocellular carcinoma.The proposed nomogram showed satisfactory validity, discrimination and clinical utility, indicating good performance for predicting depression.The variables found to be sufficiently informative and predictive to warrant inclusion in the nomogram were the patient education level, pain intensity, social support, disclosure of the hepatocellular carcinoma diagnosis to the patient and Child-Pugh class.