Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis
Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis
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DOI：
10.1016/j.psychres.2013.12.022
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发表时间：
2014-03-30
影响因子：
11.3
通讯作者：
Tso, Patrick
中科院分区：
文献类型：
--
作者：
McNamara, Robert K.;Rider, Therese;Tso, Patrick
本研究调查了正常对照（n=15）和双相情感障碍（BD, n=15）、重度抑郁症（MDD, n=15）和精神分裂症（SZ, n=15）患者死后颞上回（STG）的脂肪酸组成，这是一个涉及情绪处理的皮质区域。为了进行比较，在多发性硬化症患者（MS, n=15）和正常对照（n=15）的单独队列中测定了STG脂肪酸组成。与对照组相比，BD患者，而非MDD或SZ患者，表现出饱和脂肪酸（SFA）棕榈酸（16:0）、硬脂酸（18:0）、多不饱和脂肪酸（PUPA）亚油酸（18:2n-6）、花生四烯酸（20:4n-6）和二十二碳六烯酸（22:6n-3）的异常升高，单不饱和脂肪酸（MUFA）油酸（18:1n-9）的异常降低。总MUFA/SFA和18:1/18:0比值在BD患者STG中较低，且与总PUFA组成呈负相关。MS患者表现出与BD患者相似的脂肪酸异常模式，包括PUPA升高和18:1:18:0比降低。总的来说，这些数据表明BD患者在STG中表现出一种在MOD和SZ患者中没有观察到的脂肪酸异常模式，与MS患者非常相似。2013爱思唯尔爱尔兰有限公司版权所有。
This study investigated the fatty acid composition of the postmortem superior temporal gyrus (STG), a cortical region implicated in emotional processing, from normal controls (n=15) and patients with bipolar disorder (BD, n=15), major depressive disorder (MDD, n=15), and schizophrenia (SZ, n=15). For comparative purposes, STG fatty acid composition was determined in a separate cohort of multiple sclerosis patients (MS, n=15) and normal controls (n=15). Compared with controls, patients with BD, but not MDD or SZ, exhibited abnormal elevations in the saturated fatty acids (SFA) palmitic acid (16:0), stearic acid (18:0), the polyunsaturated fatty acids (PUPA) linoleic acid (18:2n-6), arachidonic acid (20:4n-6), and docosahexaenoic acid (22:6n-3), and reductions in the monounsaturated fatty acid (MUFA) oleic acid (18:1n-9). The total MUFA/SFA and 18:1/18:0 ratios were lower in the STG of BD patients and were inversely correlated with total PUFA composition. MS patients exhibited a pattern of fatty acid abnormalities similar to that observed in BD patients including elevated PUPA and a lower 18:1/18:0 ratio. Collectively, these data demonstrate that BD patients exhibit a pattern of fatty acid abnormalities in the STG that is not observed in MOD and SZ patients and closely resembles MS patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.