The Contribution of the Y Chromosome to Hybrid Male Sterility in House Mice
The Contribution of the Y Chromosome to Hybrid Male Sterility in House Mice
复制标题
DOI：
10.1534/genetics.112.141804
复制
发表时间：
2012-08-01
期刊：
影响因子：
3.3
通讯作者：
Nachman, Michael W.
中科院分区：
文献类型：
--
作者：
Campbell, Polly;Good, Jeffrey M.;Nachman, Michael W.
异性交配的杂交不育是动物物种形成的一个共同特征。在家鼠中，小鼠肌肉X染色体对杂交种雄性不育的贡献很大。然而，目前尚不清楚F-1雄性不育是由X-Y或X-常染色体不亲和性引起的，还是两者兼而有之。我们在野生来源品系的杂交中研究了Y染色体对杂交雄性不育的贡献，其中具有X染色体和Y染色体的雄性是部分不育的，而正反交的雄性是生殖正常的。我们利用8个X导入系在F-1常染色体背景上将不同的X染色体和不同的Y染色体组合在一起，并测量了一系列雄性生殖性状。在大多数F-1男性中观察到生殖缺陷，而不考虑Y染色体的基因型。尽管如此，我们还是发现了家养分枝杆菌Y和X分枝杆菌肌肉上的一个间隔之间的负面相互作用的证据，这导致了精子形态的异常。因此，虽然F-1雄性不育主要是由X-常染色体不亲和性引起的，但X-Y不亲和性在某些方面也是不育的原因。
Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F-1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of both. We investigated the contribution of the M. musculus domesticus Y chromosome to hybrid male sterility in a cross between wild-derived strains in which males with a M. m. musculus X chromosome and M. m. domesticus Y chromosome are partially sterile, while males from the reciprocal cross are reproductively normal. We used eight X introgression lines to combine different X chromosome genotypes with different Y chromosomes on an F-1 autosomal background, and we measured a suite of male reproductive traits. Reproductive deficits were observed in most F-1 males, regardless of Y chromosome genotype. Nonetheless, we found evidence for a negative interaction between the M. m. domesticus Y and an interval on the M. m. musculus X that resulted in abnormal sperm morphology. Therefore, although F-1 male sterility appears to be caused mainly by X-autosome incompatibilities, X-Y incompatibilities contribute to some aspects of sterility.