High expression of NDRG3 correlates with poor prognosis in gastric cancer patients
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients
复制标题
NDRG3的高表达与胃癌患者的不良预后相关。
DOI：
10.17235/reed.2021.7723/2020
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发表时间：
2021-01-01
影响因子：
2
通讯作者：
Shao, Shihe
中科院分区：
文献类型：
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作者：
Liu, Yun;Xia, Jinxuan;Shao, Shihe
N-myc下游调节基因3（NDRG3）是NDRG家族的重要成员，与恶性肿瘤有关。然而，NDRG3 与胃癌（GC）患者之间的关系尚不清楚。 Western blot、qRT-PCR和IHC检测了GC细胞系和GC组织中NDRG3的表达，公共数据库分析了GC患者中NDRG3及其与EBV感染的关系。 NDRG3 在 GC 细胞系和组织中表达上调； IHC 数据表明NDRG3 与组织学分级相关（p=0.006），并且可以影响患者的生存曲线。因此，NDRG3可能作为GC预后的新预测因子。
N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family, it linked with malignant tumors. However, the relationship between NDRG3 with gastric cancer (GC) patients is vague. Western blot, qRT-PCR and IHC detected the expression of NDRG3 in GC cell lines and GC tissues, public databases analyzed NDRG3 in GC patients and the association with EBV infection. NDRG3 was up-regulated in GC cell lines and tissues; IHC data suggested that NDRG3 was correlated with histologic grade (p=0.006), and it can affect patients' survival curve. Thus, NDRG3 may be served as a novel predictor in GC prognosis.