INTRINSIC GROWTH-CONTROL IN THE IMAGINAL PRIMORDIA OF DROSOPHILA, AND THE AUTONOMOUS ACTION OF A LETHAL MUTATION CAUSING OVERGROWTH
INTRINSIC GROWTH-CONTROL IN THE IMAGINAL PRIMORDIA OF DROSOPHILA, AND THE AUTONOMOUS ACTION OF A LETHAL MUTATION CAUSING OVERGROWTH
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DOI：
10.1016/0012-1606(85)90317-3
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发表时间：
1985-01-01
影响因子：
2.7
通讯作者：
LEVINSON, P
中科院分区：
文献类型：
--
作者：
BRYANT, PJ;LEVINSON, P
果蝇成虫盘中的细胞增殖似乎受到盘内在机制的调节，该机制涉及局部细胞相互作用，也控制分化模式的形成。这种生长控制机制在突变致死巨盘l（2）gd纯合子动物中被打破，这些动物的幼虫期比正常的要长9天。在此期间，细胞增殖继续在成虫盘和唾液腺、前肠和后肠的成虫环中进行，使得这些组织变得非常过度生长。当从三龄幼虫中期的野生型翅盘被删除，并培养了28天的野生型雌性成虫主机，他们的增长和终止增长的细胞数量接近，这将达到原位的时间pupariation。l（2）gd纯合子的翅盘在野生型寄主中生长迅速，持续生长，达到巨大的尺寸，并获得异常的折叠模式。在野生型宿主中培养这些组织期间，突变体成虫环的过度生长也继续。在这个突变体的过度生长是由于在成虫原基，这需要一个延长的幼虫期原位表达的自主缺陷。
Cell proliferation in Drosophila imaginal discs appears to be regulated by a disc-intrinsic mechanism involving local cell interactions that also control the formation of patterns of differentiation. This growth-control mechanism breaks down in animals homozygous for the mutation lethal (2) giant discs l(2)gd which remain as larvae for up to 9 days longer than normal. During the time cell proliferation continues in the imaginal discs and in the imaginal rings for the salivary glands, foregut and hindgut, so that these tissues become greatly overgrown. When wild-type wing discs from mid-third instar larvae were removed and cultured for up to 28 days in wild-type female adult hosts, they grew and terminated growth at a cell number close to that which would be attained in situ by the time of pupariation. Wing discs from l(2)gd homozygotes grew rapidly and continuously when cultivated in wild-type hosts, reached an enormous size and acquired abnormal folding patterns. Overgrowth of mutant imaginal rings also continued during culture of these tissues in wild-type hosts. Overgrowth in this mutant is due to an autonomous defect in the imaginal primordia, which requires an extended larval period for its expression in situ.