Platelet Activation Dynamics Evaluated Using Platelet-Derived Microparticles in Kawasaki Disease
Platelet Activation Dynamics Evaluated Using Platelet-Derived Microparticles in Kawasaki Disease
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DOI：
10.1253/circj.cj-12-1037
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发表时间：
2014-01-01
影响因子：
3.3
通讯作者：
Ikeda, Kazuyuki
中科院分区：
文献类型：
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作者：
Yahata, Tomoyo;Suzuki, Chinatsu;Ikeda, Kazuyuki
背景：川崎病（KD）患者血小板动力学及抗血小板治疗的效果尚不清楚。本研究的目的是阐明血小板活化动力学在急性期KD患者通过测定血小板衍生微粒（PDMPs）。方法和结果：在18例急性KD患者的血小板衍生微粒（PDMPs）水平测定ELISA。18例患者中，14例接受口服阿司匹林和静脉注射免疫球蛋白（IVIG），4例仅口服阿司匹林。在IVIG输注前、输注后立即和输注后10-14天采集血液样本;此后，在发病后1个月、2个月和3个月采集血液样本。急性期KD患儿阿司匹林治疗前血浆孕酮水平明显高于正常对照组（P
Background: Little is known about the platelet dynamics and the effect of antiplatelet therapy in Kawasaki disease (KD). The aim of this study was to clarify platelet activation dynamics in acute-phase KD patients by assaying platelet-derived microparticles (PDMPs).Methods and Results: The PDMP level in 18 patients with acute KD was measured on ELISA. Of the 18 patients, 14 were receiving oral aspirin and i.v. immunoglobulin (IVIG) and 4, oral aspirin alone. Blood samples were drawn before, immediately after, and 10-14 days after IVIG infusion; thereafter, at 1, 2, and 3 months after the onset of disease. PDMP level before aspirin treatment was significantly higher in acute-phase KD patients than in the control subjects with common febrile diseases (P