Focal laser ablation for localized prostate cancer: principles, clinical trials, and our initial experience.
Focal laser ablation for localized prostate cancer: principles, clinical trials, and our initial experience.
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局部前列腺癌的聚焦激光消融：原理、临床试验和我们的初步经验。
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
H. Lepor
中科院分区：
文献类型：
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作者：
Ted Lee;Neil Mendhiratta;D. Sperling;H. Lepor
前列腺癌的局灶性治疗是一种不断发展的治疗策略，其破坏前列腺的预定义区域，该区域具有临床意义的疾病。虽然长期的肿瘤控制尚未得到证实，但局部治疗与治疗相关的发病率显着降低相关。聚焦激光消融是一种新兴的方式，具有几个优点，最值得注意的是实时磁共振成像（MRI）兼容性。本综述介绍了激光消融的原理，多参数MRI在划定前列腺癌的重要部位中的作用，已发表的临床研究的总结，以及我们对23例患者的初步经验，选择局部前列腺消融候选人的标准，以及对未来方向的推测。
Focal therapy of prostate cancer is an evolving treatment strategy that destroys a predefined region of the prostate gland that harbors clinically significant disease. Although long-term oncologic control has yet to be demonstrated, focal therapy is associated with a marked decrease in treatment-related morbidity. Focal laser ablation is an emerging modality that has several advantages, most notably real-time magnetic resonance imaging (MRI) compatibility. This review presents the principles of laser ablation, the role of multiparametric MRI for delineating the site of significant prostate cancer, a summary of published clinical studies, and our initial experience with 23 patients, criteria for selecting candidates for focal prostate ablation, and speculation regarding future directions.