Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah Virus infection
Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah Virus infection
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DOI：
10.1128/aac.50.5.1768-1772.2006
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发表时间：
2006-05-01
影响因子：
4.9
通讯作者：
Deubel, V
中科院分区：
文献类型：
--
作者：
Georges-Courbot, MC;Contamin, H;Deubel, V
临床非随机试验证明利巴韦林在治疗严重尼帕病毒引起的脑炎患者中具有一定疗效。我们在此报告，EICAR（利巴韦林的 5-乙炔基类似物）以及 OMP 脱羧酶抑制剂 6-氮杂尿苷和吡唑呋林在体外对尼帕病毒复制具有很强的抗病毒活性。在感染致死剂量尼帕病毒的仓鼠中进一步测试了利巴韦林和 6-氮杂尿苷。将这些小分子抑制剂的活性与干扰素诱导剂聚(1)-聚(C，U)的活性进行比较。利巴韦林和 6-氮杂尿苷都能够延迟但不能预防尼帕病毒引起的死亡。从感染当天到感染后 10 天，每天按 3 毫克/公斤体重服用聚 (I)-聚 (C12U)，可防止 6 只受感染动物中的 5 只死亡。
Clinical nonrandomized trials demonstrate some efficacy for ribavirin in the treatment of patients with severe Nipah virus-induced encephalitis. We report here that EICAR, the 5-ethynyl analogue of ribavirin, and the OMP-decarboxylase inhibitors 6-aza-uridine and pyrazofurin have strong antiviral activity against Nipah virus replication in vitro. Ribavirin and 6-aza-uridine were tested further in hamsters infected with a lethal dose of Nipah virus. The activity of these small-molecule inhibitors was compared with that of the interferon inducer poly (1) -poly (C, U). Both ribavirin and 6-aza-uridine were able to delay but not prevent Nipah virus-induced mortality. Poly(I)-poly(C12U), at 3 mg/kg of body weight daily from the day of infection to 10 days postinfection, prevented mortality in 5 of 6 infected animals.