Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-α and β-chemokine receptors in congenital CMV disease
Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-α and β-chemokine receptors in congenital CMV disease
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DOI：
10.1086/344238
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发表时间：
2002-10-15
影响因子：
6.4
通讯作者：
Hayward, GS
中科院分区：
文献类型：
--
作者：
Arav-Boger, R;Willoughby, RE;Hayward, GS
一些先天性巨细胞病毒（CMV）感染会导致新生儿疾病，而另一些则没有相关的后遗症。为了探讨病毒基因作为毒力决定因素的可能作用，对33例先天性CMV感染患者的UL 144肿瘤坏死因子（TNF）-α样受体基因、US 28 β-趋化因子受体基因和UL 55包膜糖蛋白B基因的部分进行了测序。检测到3种主要的UL 144亚型（A、B和C）和2种重组体（A/C和A/B）。最不常见的UL 144亚型（A、C、A/C和A/B）感染与不利的疾病结局相关（P = 0.04）。US 28和UL 55基因的特定亚型与结果之间没有关联（分别为P = 0.864和P = 0.765）。在10例尸检中的8例组织中检测到多种基因型（意味着多重感染）。因此，CMV编码的TNF-α样受体的多态性似乎与先天性CMV疾病有关。其他CMV多态性与新生儿感染、移植和获得性免疫缺陷综合征相关CMV疾病的潜在相关性应进一步评估。
Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-alpha-like receptor gene, the US28 beta-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P = .04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P = .864 and P = .765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-alpha-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.