Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ.
Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ.
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DOI：
10.3389/fendo.2021.749125
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发表时间：
2021
影响因子：
5.2
通讯作者：
Tong Q
中科院分区：
文献类型：
--
作者：
Yang X;Zhang X;Yang W;Yu H;He Q;Xu H;Li S;Shang Z;Gao X;Wang Y;Tong Q
肠道微生物群已成为寄主新陈代谢的关键调节器。越来越多的证据表明，肠道微生物区系参与了各种人类疾病的发展。这种联系依赖于肠道微生物区系的结构和代谢物。肠道微生物区系将寄主摄取的食物代谢成一系列代谢物，包括短链脂肪酸、次级胆汁酸、三甲胺N-氧化物和支链氨基酸，通过激活许多信号通路来影响寄主的生理过程。在这篇综述中，我们首先总结了肠道微生物区系影响脂肪组织功能障碍和代谢过程从而导致心血管疾病的各种机制，重点介绍了肠道微生物、其代谢产物和宿主代谢活动之间的复杂相互作用。此外，我们还调查了针对肠道微生物区系的脂肪组织功能障碍的临床治疗现状。最后，我们讨论了在将这一研究领域转化为日常临床实践之前仍需解决的挑战。
The gut microbiome has emerged as a key regulator of host metabolism. Accumulating evidence has indicated that the gut microbiota is involved in the development of various human diseases. This association relies on the structure and metabolites of the gut microbiota. The gut microbiota metabolizes the diet ingested by the host into a series of metabolites, including short chain fatty acids, secondary bile acids, trimethylamine N-oxide, and branched-chain amino acids, which affects the physiological processes of the host by activating numerous signaling pathways. In this review, we first summarize the various mechanisms through which the gut microbiota influences adipose tissue dysfunction and metabolic processes that subsequently cause cardiovascular diseases, highlighting the complex interactions between gut microbes, their metabolites, and the metabolic activity of the host. Furthermore, we investigated the current status of clinical therapies for adipose tissue dysfunction directed at the gut microbiota. Finally, we discuss the challenges that remain to be addressed before this field of research can be translated to everyday clinical practice.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1186/1476-9255-9-48
发表时间：
2012-11-28
期刊：
Journal of inflammation (London, England)
影响因子：
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发表时间：
2010-08-01
影响因子：
4.5
作者：
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影响因子：
37.8
作者：
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DOI：
10.1152/ajpendo.00302.2006
发表时间：
2007-03-01
影响因子：
5.1
作者：
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通讯作者：
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