The distribution of histaminergic axons in the superior colliculus of the cat.
The distribution of histaminergic axons in the superior colliculus of the cat.
复制标题
猫上丘组胺能轴突的分布。
DOI：
10.1016/0306-4522(93)90321-6
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发表时间：
1993
期刊：
影响因子：
3.3
通讯作者：
Uhlrich,DJ
中科院分区：
文献类型：
--
作者：
Manning,KA;Uhlrich,DJ
本文用组胺抗体在猫脑内用电化学方法研究了下丘脑向上级丘的组胺能投射。脑内组胺能纤维的来源是下丘脑后部的一组神经元，主要位于腹外侧和室周区域，统称为结节乳头核。上级丘的所有层，包括浅层、中层和深层，以及中央灰质，都覆盖着组胺免疫反应阳性的轴突纤维。总体而言，标记在上级丘是中等密度相比，在猫脑的其他位置，在纤维密度有一些变化。个别标记的纤维类似于组胺能纤维先前描述的大脑。标记的轴突纤维很少分支，并有许多直径通常为1 μm或更小，但直径可达2.5 μm的过路血管。静脉曲张的大小在丘的不同深度有显着差异。组胺能投射似乎是独立的，从下丘脑背侧区的神经元的中间和深coliculus.These结果表明，从下丘脑结节乳头核的组胺能投射广泛的整个上级丘的离散区域的明显非组胺能投射。组胺被认为是大脑中的一种神经调节剂，能够影响猫上级丘每一层的感觉和运动相关过程。
The histaminergic projection from the hypothalamus to the superior colliculus was examined immunohistochemically in the cat brain using an antibody to histamine. The source of histaminergic fibers in the brain is a group of neurons in the posterior hypothalamus, located primarily in ventrolateral and periventricular regions and collectively referred to as the tuberomammillary nucleus.All laminae of the superior colliculus—including the superficial, intermediate, and deep layers, as well as the central gray—were blanketed with histamine-immunoreactive axonal fibers. Overall, labeling in the superior colliculus was moderately dense compared to other locations in the cat brain, with some variation in fiber density. Individual labeled fibers resembled histaminergic fibers described previously in the brain. Labeled axonal fibers showed infrequent branching and were beaded with numerousen passantvaricosities that were typically 1 μm or smaller, but as large as 2.5 μm in diameter. Varicosity size differed significantly at different depths in the colliculus. The histaminergic projection appears to be separate from a previously reported, apparently non-histaminergic projection from neurons in the dorsal hypothalamic area to discrete regions of intermediate and deep colliculus.These results indicate that the histaminergic projection from the tuberomammillary nucleus of the hypothalamus projects extensively throughout the superior colliculus. Histamine, which is believed to act as a neuromodulator in the brain, is in a position to influence sensory and motor-related processes in every layer of the cat superior colliculus.