Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983).
Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983).
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动脉粥样硬化犬的临床和病理结果：21 例（1970-1983 年）。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
P. Fox
中科院分区：
文献类型：
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作者：
S. Liu;L. Tilley;J. Tappe;P. Fox
在14年的时间里，21只狗在尸检时被诊断为动脉粥样硬化。9只狗死亡，12只因为与疾病有关的并发症而被安乐死。平均年龄为8.5 ± 0.5岁; 18只犬为雄性。三个品种（迷你雪纳瑞，杜宾犬和拉布拉多寻回犬）有较高的患病率比其他品种的犬尸检人口的动物医疗中心。最常见的临床体征是嗜睡、厌食、虚弱、呼吸困难、虚脱和呕吐。高胆固醇血症，甲减，甲状腺功能减退症是常见的受影响的狗测试，蛋白电泳显示高值α 2和β组分在所有测试的狗。心电图显示传导异常和心肌梗死的7只狗。尸检显示受影响的动脉（包括冠状动脉、心肌动脉、肾动脉、颈动脉、甲状腺动脉、肠动脉、胰腺动脉、脾动脉、胃动脉、前列腺动脉、脑动脉和肠系膜动脉）呈黄白色、增厚和结节状，管腔狭窄。在心肌中也观察到心肌纤维化和梗死。在组织学上，受影响的动脉壁含有泡沫细胞或空泡、囊性空间、矿化物质、有或无内膜侵蚀的碎片和退化的肌肉细胞。
Atherosclerosis was diagnosed on necropsy in 21 dogs in a 14-year period. Nine dogs died and 12 were euthanatized because of complications associated with the disease. The mean age was 8.5 +/- 0.5 years; 18 dogs were male. Three breeds (Miniature Schnauzer, Doberman Pinscher, and Labrador Retriever) had a higher prevalence of the disease than other breeds in the canine necropsy population of The Animal Medical Center. Most common clinical signs were lethargy, anorexia, weakness, dyspnea, collapse, and vomiting. Hypercholesterolemia, lipidemia, and hypothyroidism were common in affected dogs tested, and protein electrophoresis revealed high values for alpha 2 and beta fractions in all dogs tested. Electrocardiography indicated conduction abnormalities and myocardial infarction in 3 of 7 dogs. Necropsy revealed that affected arteries (including coronary, myocardial, renal, carotid, thyroidal, intestinal, pancreatic, splenic, gastric, prostatic, cerebral, and mesenteric) were yellow-white, thick and nodular, and had narrow lumens. Myocardial fibrosis and infarction also were observed in the myocardium. Histologically, affected arterial walls contained foamy cells or vacuoles, cystic spaces, mineralized material, debris with or without eroded intima, and degenerated muscle cells.